Accumulation of intracellular damage is an almost universal hallmark of aging. An improved
understanding of the systems that contribute to cellular protein quality control has shed light …

All cells count on precise mechanisms that regulate protein homeostasis to maintain a stable
and functional proteome. Alterations in these fine-tuned mechanisms underlie the …

Ensuring cellular protein homeostasis, or proteostasis, requires precise control of protein
synthesis, folding, conformational maintenance, and degradation. A complex and adaptive …

Ageing is a major risk factor for the development of many diseases, prominently including
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …

The functional health of the proteome is determined by properties of the proteostasis
network (PN) that regulates protein synthesis, folding, macromolecular assembly …

Proteome maintenance is crucial to cellular health and viability, and is typically thought to be
controlled in a cell-autonomous manner. However, recent evidence indicates that protein …

The maintenance of the proteome is essential to preserve cell functionality and the ability to
respond and adapt to the changing environment. This is regulated by the proteostasis …

Protein turnover is an effective way of maintaining a functional proteome, as old and
potentially damaged polypeptides are destroyed and replaced by newly synthesized copies …

Loss of protein homeostasis (proteostasis) is a common feature of aging and disease that is
characterized by the appearance of nonnative protein aggregates in various tissues. Protein …

The protein components of eukaryotic cells face acute and chronic challenges to their
integrity. Eukaryotic protein homeostasis, or proteostasis, enables healthy cell and …