Prenatal GABAB receptor agonist administration corrects the inheritance of autism-like core behaviors in offspring of mice prenatally exposed to valproic acid

S Jiang, M He, L Xiao, Y Sun, J Ding, W Li… - Frontiers in …, 2022 - frontiersin.org
This study was performed to evaluate the effects of prenatal baclofen (a GABAB receptor
agonist) treatment on the inheritance of autism-like behaviors in valproic acid (VPA) …

The valproic acid-induced rodent model of autism

C Nicolini, M Fahnestock - Experimental neurology, 2018 - Elsevier
Autism is a lifelong neurodevelopmental disorder characterized by impairments in social
communication and interaction and by repetitive patterns of behavior, interests and activities …

Pharmacological activation of group-II metabotropic glutamate receptors corrects a schizophrenia-like phenotype induced by prenatal stress in mice

F Matrisciano, P Tueting, S Maccari, F Nicoletti… - …, 2012 - nature.com
Prenatal exposure to restraint stress causes long-lasting changes in neuroplasticity that
likely reflect pathological modifications triggered by early-life stress. We found that the …

[PDF][PDF] Valproic acid and autism spectrum disorder: from clinical observations to animal studies

S Roux, JL Bossu - Neurology, 2017 - researchgate.net
Autism spectrum disorder (ASD) is a neurodevelopmental pathology clinically characterized
by persistent deficits in social communication and social interactions associated with …

Distinct defects in synaptic differentiation of neocortical neurons in response to prenatal valproate exposure

Y Iijima, K Behr, T Iijima, B Biemans, J Bischofberger… - Scientific reports, 2016 - nature.com
Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental
disorders characterized by impairments in social interactions and stereotyped behaviors …

Developmental disruption of amygdala transcriptome and socioemotional behavior in rats exposed to valproic acid prenatally

CE Barrett, TM Hennessey, KM Gordon, SJ Ryan… - Molecular autism, 2017 - Springer
Background The amygdala controls socioemotional behavior and has consistently been
implicated in the etiology of autism spectrum disorder (ASD). Precocious amygdala …

Behavior and serotonergic disorders in rats exposed prenatally to valproate: a model for autism

D Dufour-Rainfray, P Vourc'h, AM Le Guisquet… - Neuroscience …, 2010 - Elsevier
In order to explore whether some aspects of the autistic phenotype could be related to
impairment of the serotonergic system, we chose an animal model which mimics a potential …

BALB/c female subjected to valproic acid during gestational period exhibited greater microglial and behavioral changes than male mice: A significant contra intuitive …

ALG Dos Santos, ERLP de Leão… - International Journal …, 2021 - Wiley Online Library
Most animal model studies of autism spectrum disorders (ASD) were performed in males.
Thus, little is known about the mechanisms underlying disease progression in females …

5-HT1A-receptor agonist modified amygdala activity and amygdala-associated social behavior in a valproate-induced rat autism model

CC Wang, HC Lin, YH Chan, PW Gean… - International Journal …, 2013 - academic.oup.com
Accumulating evidence suggests that dysfunction of the amygdala is related to abnormal
fear processing, anxiety, and social behaviors noted in autistic spectrum disorders (ASDs) …

Suppression of NMDA receptor function in mice prenatally exposed to valproic acid improves social deficits and repetitive behaviors

J Kang, E Kim - Frontiers in molecular neuroscience, 2015 - frontiersin.org
Animals prenatally exposed to valproic acid (VPA), an antiepileptic agent, have been used
as a model for autism spectrum disorders (ASDs). Previous studies have identified …