Autism spectrum disorder (ASD) is characterized by impairment of social communication,
repetitive behavior and restrictive interest. The risk of ASD is strongly associated with the …

The finding that the mGlu2/3 metabotropic glutamate receptor agonist, LY404039, improves
clinical symptoms in schizophrenia warrants a search for a possible interaction between …

The activation of Group II metabotropic glutamate 2/3 (mGlu 2/3) receptors reduces the
excessive glutamate release that is hypothesized to be associated with neurodegenerative …

Valproic acid (VPA) administered to mice during the early postnatal period causes social,
cognitive, and motor deficits similar to those observed in humans with autism spectrum …

The prefrontal cortex has been extensively implicated in autism to explain deficits in
executive and other higher brain functions related to cognition, language, sociability and …

Synaptic alterations concomitant with neuroinflammation have been described in patients
and experimental models of autism spectrum disorder (ASD). However, the role of microglia …

Sodium valproate (VPA) is the most widely used antiepileptic drug and is increasingly also
being used for several non-epileptic indications including migraines and bipolar disorder. It …

Attention is foundational to efficient perception and optimal goal driven behavior. Intact
attentional processing is crucial for the development of social and communication skills …

Group II metabotropic (mGlu II) receptor subtypes mGlu2 and mGlu3 are important
modulators of synaptic plasticity and glutamate release in the brain. Accordingly, several …

Maternal use of valproic acid (VPA) during pregnancy has been implicated in the aetiology
of autism spectrum disorders in children, and rodents prenatally exposed to VPA showed …