Older age is a strong shared risk factor for many chronic diseases, and there is increasing
interest in identifying aging biomarkers. Here, a proteomic analysis of 1301 plasma proteins …

The molecular changes that occur with aging are not well understood,,–. Here, we
performed longitudinal and deep multiomics profiling of 106 healthy individuals from 29 to …

Using samples from the New England Centenarian Study (NECS), we sought to characterize
the serum proteome of 77 centenarians, 82 centenarians' offspring, and 65 age‐matched …

To characterize the proteomic signature of chronological age, 1,301 proteins were
measured in plasma using the SOMAscan assay (SomaLogic, Boulder, CO, USA) in a …

Our understanding of Alzheimer's disease (AD) pathophysiology remains incomplete. Here
we used quantitative mass spectrometry and coexpression network analysis to conduct the …

The plasma proteomic changes that precede the onset of dementia could yield insights into
disease biology and highlight new biomarkers and avenues for intervention. We quantified …

The biological process of aging is believed to be the result of an accumulation of cellular
damage to biomolecules. Although there are numerous studies addressing mutation …

In the central nervous system, ageing results in a precipitous decline in adult neural
stem/progenitor cells and neurogenesis, with concomitant impairments in cognitive …

The blood contains a treasure trove of previously unstudied biomarkers that could reflect the
ongoing physiologic state of all tissues. Every cell in the body leaves a record of its …

The vascular interface of the brain, known as the blood–brain barrier (BBB), is understood to
maintain brain function in part via its low transcellular permeability,–. Yet, recent studies …