Ageing is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. Despite rapid advances over recent years …

To elucidate the proteomic features of aging in plasma, the subproteome targeted by the
SOMAscan assay was profiled in blood samples from 202 females from the TwinsUK cohort …

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Diminishing potential to replace damaged tissues is a hallmark for ageing of somatic stem
cells, but the mechanisms remain elusive. Here, we present proteome-wide atlases of age …

Individuals of the same age may not age at the same rate. Quantitative biomarkers of aging
are valuable tools to measure physiological age, assess the extent of 'healthy aging', and …

Proteins are effector molecules that mediate the functions of genes, and modulate
comorbidities,,,,,,–, behaviors and drug treatments. They represent an enormous potential …

The advent of proteomics offers an unprecedented opportunity to predict dementia onset.
We examined this in data from 52,645 adults without dementia in the UK Biobank, with 1,417 …

Alzheimer's disease (AD) pathology develops many years before the onset of cognitive
symptoms. Two pathological processes—aggregation of the amyloid-β (Aβ) peptide into …

A diverse set of biological processes have been implicated in the pathophysiology of
Alzheimer's disease (AD) and related dementias. However, there is limited understanding of …

The mammalian brain contains neurogenic niches that comprise neural stem cells and other
cell types. Neurogenic niches become less functional with age, but how they change during …