Aging is a complex process regulated by multiple cellular pathways, including the
proteostasis network. The proteostasis network consists of molecular chaperones, stress …

Length and quality of life are important to us all, yet identification of promising drug targets
for human aging using genetics has had limited success. In the present study, we combine …

Although systemic diseases take the biggest toll on human health and well-being,
increasingly, a failing brain is the arbiter of a death preceded by a gradual loss of the …

In advanced age, some individuals maintain a stable cognitive trajectory while others
experience a rapid decline. Such variation in cognitive trajectory is only partially explained …

Alzheimer's disease is a pervasive neurodegenerative disorder, the molecular complexity of
which remains poorly understood. Here, we analysed 80,660 single-nucleus transcriptomes …

Proteomic studies of human Alzheimer's disease brain tissue have potential to identify
protein changes that drive disease, and to identify new drug targets. Here, we analyse 38 …

Antiaging therapies show promise in model organism research. Translation to humans is
needed to address the challenges of an aging global population. Interventions to slow …

Aging is a prominent risk factor for neurodegenerative disorders (NDDs); however, the
molecular mechanisms rendering the aged brain particularly susceptible to …

Objective Previous gene expression analysis identified a network of coexpressed genes that
is associated with β‐amyloid neuropathology and cognitive decline in older adults. The …

Ageing drives changes in neuronal and cognitive function, the decline of which is a major
feature of many neurological disorders. The hippocampus, a brain region subserving roles …