The ageing of the human brain is a cause of cognitive decline in the elderly and the major
risk factor for Alzheimer's disease. The time in life when brain ageing begins is undefined …

Cellular senescence, which is characterized by an irreversible cell-cycle arrest
accompanied by a distinctive secretory phenotype, can be induced through various …

Mitochondria are multifunctional organelles whose dysfunction leads to neuromuscular
degeneration and ageing. The multi-functionality poses a great challenge for understanding …

Aging drives cognitive and regenerative impairments in the adult brain, increasing
susceptibility to neurodegenerative disorders in healthy individuals,,,. Experiments using …

Age-associated chronic inflammation (inflammageing) is a central hallmark of ageing, but its
influence on specific cells remains largely unknown. Fibroblasts are present in most tissues …

The cellular proteome is a complex microcosm of structural and regulatory networks that
requires continuous surveillance and modification to meet the dynamic needs of the cell. It is …

Ageing is a critical factor in spinal-cord-associated disorders, yet the ageing-specific
mechanisms underlying this relationship remain poorly understood. Here, to address this …

A progressive loss of protein homeostasis is characteristic of aging and a driver of
neurodegeneration. To investigate this process quantitatively, we characterized proteome …

Understanding the tissue-specific genetic controls of protein levels is essential to uncover
mechanisms of post-transcriptional gene regulation. In this study, we generated a genomic …

Dementia in Alzheimer's disease progresses alongside neurodegeneration,,–, but the
specific events that cause neuronal dysfunction and death remain poorly understood. During …