The protein components of eukaryotic cells face acute and chronic challenges to their
integrity. Eukaryotic protein homeostasis, or proteostasis, enables healthy cell and …

Genetic studies indicate that protein homeostasis is a major contributor to metazoan
longevity. Collapse of protein homeostasis results in protein misfolding cascades and the …

Find drugs that delay many diseases of old age Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the …

The precise mechanisms that lead to cognitive decline in Alzheimer's disease are unknown.
Here we identify amyloid-plaque-associated axonal spheroids as prominent contributors to …

During the past century, treatments for the diseases of youth and middle age have helped
raise life expectancy significantly. However, cognitive decline has emerged as one of the …

[illus. 1] Seldom does a single piece of research prompt the US Congress to pass a
resolution urging continued funding to drive a new diagnostic test towards the clinic. But …

Interventions that delay ageing mobilize mechanisms that protect and repair cellular
components,,, but it is unknown how these interventions might slow the functional decline of …

Neurodegenerative diseases are a growing burden, and there is an urgent need for better
biomarkers for diagnosis, prognosis, and treatment efficacy. Structural and functional brain …

Abstract The Pharma Proteomics Project is a precompetitive biopharmaceutical consortium
characterizing the plasma proteomic profiles of 54,219 UK Biobank participants. Here we …

Effective network analysis of protein data requires high-quality proteomic datasets. Here, we
report a near doubling in coverage of the C. elegans adult proteome, identifying> 11,000 …