Activation of mGluR2/3 underlies the effects of N-acetylcystein on amygdala-associated autism-like phenotypes in a valproate-induced rat model of autism
YW Chen, HC Lin, MC Ng, YH Hsiao… - Frontiers in Behavioral …, 2014 - frontiersin.org
Autism-like phenotypes in male valproate (VPA)-exposed offspring have been linked to high
glutamatergic neurotransmission in the thalamic-amygdala pathway. Glial cystine/glutamate …
glutamatergic neurotransmission in the thalamic-amygdala pathway. Glial cystine/glutamate …
N-acetylcysteine mitigates social dysfunction in a rat model of autism normalizing glutathione imbalance and the altered expression of genes related to synaptic …
S Schiavi, P La Rosa, S Petrillo, E Carbone… - Frontiers in …, 2022 - frontiersin.org
Prenatal exposure to valproic acid (VPA) is a risk factor for autism spectrum disorder (ASD)
in humans and it induces autistic-like behaviors in rodents. Imbalances between GABAergic …
in humans and it induces autistic-like behaviors in rodents. Imbalances between GABAergic …
Alleviation of N-Methyl-d-Aspartate Receptor-Dependent Long-Term Depression via Regulation of the Glycogen Synthase Kinase-3β Pathway in the Amygdala of a …
The amygdala plays crucial roles in socio-emotional behavior and cognition, both of which
are abnormal in autism spectrum disorder (ASD). Valproic acid (VPA)-exposed rat offspring …
are abnormal in autism spectrum disorder (ASD). Valproic acid (VPA)-exposed rat offspring …
Group I and group II metabotropic glutamate receptors are upregulated in the synapses of infant rats prenatally exposed to valproic acid
S D'Antoni, S Schiavi, V Buzzelli, S Giuffrida, A Feo… - …, 2023 - Springer
Rationale Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized
by impaired social interaction and restricted/stereotyped behavior. Prenatal exposure to …
by impaired social interaction and restricted/stereotyped behavior. Prenatal exposure to …
Prenatal valproate treatment produces autistic-like behavior and increases metabotropic glutamate receptor 1A-immunoreactivity in the hippocampus of juvenile rats
F Peralta, C Fuentealba… - Molecular Medicine …, 2016 - spandidos-publications.com
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder
characterized by deficits in social communication and social interaction, and repetitive and …
characterized by deficits in social communication and social interaction, and repetitive and …
Altered expression of glutamatergic and GABAergic genes in the valproic acid-induced rat model of autism: A screening test
J Lenart, J Augustyniak, JW Lazarewicz, E Zieminska - Toxicology, 2020 - Elsevier
Autism spectrum disorders (ASD) include neurodevelopmental disorders in which
behavioral deficits can result from neuronal imbalance of excitation to inhibition (E/I) in the …
behavioral deficits can result from neuronal imbalance of excitation to inhibition (E/I) in the …
Suppression of NMDA receptor function in mice prenatally exposed to valproic acid improves social deficits and repetitive behaviors
J Kang, E Kim - Frontiers in molecular neuroscience, 2015 - frontiersin.org
Animals prenatally exposed to valproic acid (VPA), an antiepileptic agent, have been used
as a model for autism spectrum disorders (ASDs). Previous studies have identified …
as a model for autism spectrum disorders (ASDs). Previous studies have identified …
D-Cycloserine Ameliorates Autism-Like Deficits by Removing GluA2-Containing AMPA Receptors in a Valproic Acid-Induced Rat Model
Valproic acid (VPA)-exposed rat offspring have demonstrated autism spectrum disorder
(ASD) phenotypes and impaired N-methyl-D-aspartate receptor (NMDAR)-dependent long …
(ASD) phenotypes and impaired N-methyl-D-aspartate receptor (NMDAR)-dependent long …
The amygdala excitatory/inhibitory balance in a valproate-induced rat autism model
The amygdala is an important structure contributing to socio-emotional behavior. However,
the role of the amygdala in autism remains inconclusive. In this study, we used the 28–35 …
the role of the amygdala in autism remains inconclusive. In this study, we used the 28–35 …
mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism
Autism spectrum disorders (ASD) are highly disabling developmental disorders with a
population prevalence of 1–3%. Despite a strong genetic etiology, there are no current …
population prevalence of 1–3%. Despite a strong genetic etiology, there are no current …