Adjuvants play pivotal roles in vaccine development, enhancing immunization efficacy
through prolonged retention and sustained release of antigen, lymph node targeting, and …

Adjuvants enhance immunity to vaccines and experimental antigens by a variety of
mechanisms. In the past decade, many receptors and signaling pathways in the innate …

Vaccines were first introduced more than 200 years ago and have since played a key role in
the reduction of morbidity and mortality caused by infectious diseases. Many of the safest …

Highlights•Adjuvants can be incorporated into vaccines to enhance the magnitude,
functionality, breadth and durability of antigen-specific immune responses.•A deeper …

Adjuvants are substances that boost the immunogenicity of vaccines. However, most
successful vaccines have been derived empirically and are capable of inducing robust T …

Developing new vaccines against emerging pathogens or pathogens where variability of
antigenic sites presents a challenge, the inclusion of stimulators of the innate immune …

Vaccine adjuvant research is being fueled and driven by progress in the field of innate
immunity that has significantly advanced in the past two decades with the discovery of …

Using adjuvants to drive features of T cell responses to vaccine antigens is an important
technological challenge in the design of new and improved vaccines against infections …

The concept of stimulating the body's immune response is the basis underlying vaccination.
Vaccines act by initiating the innate immune response and activating antigen presenting …

Highlights•Studies suggest adjuvants could induce epigenetic reprogramming of myeloid
cells.•Reprogramming could lead to a durable state of heightened antiviral resistance.•This …