The newborn innate immune system is characterized as functionally distinct, resulting in
impaired proinflammatory responses to many stimuli and a bias toward Th2 development …

Highlights•Adjuvants can be incorporated into vaccines to enhance the magnitude,
functionality, breadth and durability of antigen-specific immune responses.•A deeper …

Infants are capable of mounting adaptive immune responses, but their ability to develop long-
lasting immunity is limited. Understanding the particularities of the neonatal adaptive …

Respiratory syncytial virus is a leading cause of morbidity and mortality in children, due in
part to their distinct immune system, characterized by impaired induction of Th 1 immunity …

The first months of life represent a period of heightened susceptibility to infection, but the
immunological differences involved are as yet incompletely understood. T cellindependent B …

Highlights•TLR based adjuvants increase immunogenicity of non-live vaccines.•NHP cell
subset phenotype and TLR expression reflects humans.•NHP model better translates …

Toward precision adjuvants: optimizing science and safety : Current Opinion in Pediatrics
Toward precision adjuvants: optimizing science and safety : Current Opinion in Pediatrics Log …

Adjuvants are indispensable components of vaccines for stimulating optimal immune
responses to non-replicating, inactivated and subunit antigens. Eliciting balanced humoral …

Finding adjuvants in order to enhance immune responses against target immunogens has
been a major and recurrent issue for the vaccine industry. It is yet to be solved, most …

Neonates are highly susceptible to intracellular pathogens, leading to high morbidity and
mortality rates. CD8+ T lymphocytes are responsible for the elimination of infected cells …