A better understanding of the mechanisms of action of human adjuvants could inform a
rational development of next generation vaccines for human use. Here, we exploited a …

Highlights•Insoluble aluminum salts have long been used to stimulate B and CD4 T cell
responses.•The need for IL-1/MyD88 for alum's adjuvancy depends on the site of …

After decades of slow progress, the last years have seen a rapid acceleration of the
development of adjuvanted vaccines which have lately been approved for human use …

New vaccines based on soluble recombinant antigens (Ags) require adjuvants to elicit long‐
lasting protective humoral and cellular immunity. Despite the importance of CD4 T helper …

Background Newborns display distinct immune responses, leaving them vulnerable to
infections and impairing immunization. Targeting newborn dendritic cells (DCs), which …

Vaccination is the most successful and cost-effective method to prevent infectious diseases.
However, many vaccine antigens have poor in vivo immunogenic potential and need …

Pathogens comprise a diverse set of immunostimulatory molecules that activate the innate
immune system during infection. The immune system recognizes distinct combinations of …

Frontiers in Immunology provides a timely summary of the many recent advances in
knowledge regarding the immune response of the mother, fetus, newborn, and young infant …

Adjuvants hold great potential in enhancing vaccine efficacy, making the understanding and
improving of adjuvants critical goals in vaccinology. The TLR7/8 agonist, 3M-052, induces …

The use of vaccines has led to tremendous decreases in disease burdens across the world.
Many challenges remain in expanding vaccine coverage to new pathogens, however, a …