Adjuvants hold great potential in enhancing vaccine efficacy, making the understanding and
improving of adjuvants critical goals in vaccinology. The TLR7/8 agonist, 3M-052, induces …

The use of vaccines has led to tremendous decreases in disease burdens across the world.
Many challenges remain in expanding vaccine coverage to new pathogens, however, a …

The initial months of life reflect an extremely challenging time for newborns as a naïve
immune system is bombarded with a large array of pathogens, commensals, and other …

Summary Interleukin-21 (IL-21) is a pleiotropic cytokine that induces expression of
transcription factor BLIMP1 (encoded by Prdm1), which regulates plasma cell differentiation …

Early life is a period of particular susceptibility to respiratory infections and symptoms are
frequently more severe in infants than in adults. The neonatal immune system is generally …

Cytokines are key regulators of the immune system that shape innate and adaptive immune
responses. An adequate balance of the cytokine environment is critical to achieve protective …

The Adjuvant System AS01 contains monophosphoryl lipid A (MPL) and the saponin QS-21
in a liposomal formulation. AS01 is included in recently developed vaccines against malaria …

The success of the World Health Organization recommended “Expanded Program of
Immunization”(EPI) and similar regional or national programs has been astounding …

Monocyte-derived human dendritic cells (MoDCs) are increasingly applied as cellular
vaccines for cancer patients. Important features for their efficacy include high migratory …

Frontiers in Immunology provides a timely summary of the many recent advances in
knowledge regarding the immune response of the mother, fetus, newborn, and young infant …