The dynamics and molecular mechanisms underlying vaccine immunity in early childhood
remain poorly understood. Here we applied systems approaches to investigate the innate …

Vaccines intended to induce a cytotoxic CD8+ T‐cell response are highly sought after.
However, some of these vaccines can be problematic if they replicate in the host. An …

Insufficient T-cell responses contribute to the increased burden of viral respiratory disease in
infancy. Neonatal dendritic cells (DCs) often provide defective activation of pathogen …

How Do Adjuvants Work? Important Considerations for New Generation Adjuvants: Immunity
Skip to Main Content Skip to Main Menu Advertisement Immunity This journal offers authors two …

Infections take their greatest toll in early life necessitating robust approaches to protect the
very young. Here, we review the rationale, current state, and future research directions for …

Type 1 conventional dendritic cells (cDC1s) are rare immune cells critical for the induction of
antigen-specific cytotoxic CD8+ T cells, although the genetic program driving human cDC1 …

Although a great public heath success, vaccines provide suboptimal protection in some
patient populations and are not available to protect against many infectious diseases …

The Bacille Calmette Guérin (BCG) vaccine is the only routine vaccination at birth that
effectively induces neonatal T-helper 1 (Th1)-polarized immune responses. The primary …

There is a critical need for adjuvants that can safely elicit potent and durable T cell-based
immunity to intracellular pathogens. Here, we report that parenteral vaccination with a …

The existence of pathogens that escape recognition by specific vaccines, the need to
improve existing vaccines and the increased availability of therapeutic (non-infectious …