Novel Compound MMV1804559 from the Global Health Priority Box Exhibits In Vitro and In Vivo Activity against Madurella mycetomatis

J Ma, K Eadie, M Schippers, A Fahal, B Laleu… - International Journal of …, 2024 - mdpi.com
Objectives: Eumycetoma is a neglected tropical disease (NTD) characterized by
subcutaneous lesions and the formation of grains. Attempts to treat eumycetoma involve a …

Anu taila, an herbal nasal drop, suppresses mucormycosis by regulating host TNF‐α response and fungal ergosterol biosynthesis

A Balkrishna, S Rastogi, B Kharayat… - Journal of applied …, 2022 - academic.oup.com
Aim The intractable, mucormycosis, caused by Mucorales primarily targets
immunocompromised individuals. The first‐line therapy, intravenous liposomal amphotericin …

[引用][C] Mucorales and mucormycosis: Recent insights and future prospects. J Fungi. 2023; 9: 335

G Tahiri, C Lax, JT Cánovas-Márquez, P Carrillo-Marín… - 2023 - europepmc.org
The classification of Mucorales encompasses a collection of basal fungi that have
traditionally demonstrated an aversion to modern genetic manipulation techniques. This …

[HTML][HTML] Identification of novel inhibitors of high affinity iron permease (FTR1) through implementing pharmacokinetics index to fight against black fungus: An in silico …

MIQ Tonmoy, SF Ahmed, I Hami, MSK Shakil… - Infection, Genetics and …, 2022 - Elsevier
Mucormycosis is a life-threatening fungal infection, particularly in immunocompromised
patients. Mucormycosis has been reported to show resistance to available antifungal drugs …

Pandemic Response Box® library as a source of antifungal drugs against Scedosporium and Lomentospora species

R Rollin-Pinheiro, MIDS Xisto, Y de Castro-Almeida… - Plos one, 2023 - journals.plos.org
Scedosporium and Lomentospora species are opportunistic filamentous fungi that cause
localized and disseminated infections in immunocompetent and immunocompromised …

A screening of the MMV Pathogen Box® reveals new potential antifungal drugs against the etiologic agents of chromoblastomycosis

RA Coelho, LS Joffe, GM Alves… - PLoS …, 2020 - journals.plos.org
Chromoblastomycosis (CBM) is a chronic subcutaneous mycosis caused by traumatic
implantation of many species of black fungi. Due to the refractoriness of some cases and …

[PDF][PDF] A comprehensive review on mucormycosis (black fungus) and its association with covid-19

S Alom, F Ali, ZK Md - Curr Trends Pharm Res, 2021 - researchgate.net
Background: Mucormycosis is an infection caused by a group of filamentous molds belong
to order Mucorales and class Zygomycetes. Mucormycosis is commonly known as black …

Combination therapy in Mucormycosis: Current evidence from the world literature, a mini review

DS Meena, D Kumar, GK Bohra - Journal of Medical Mycology, 2023 - Elsevier
The emergence of Mucorales infections is an urgent global public health threat rapidly
disseminating during the current COVID-19 pandemic. Invasive mucormycosis carries …

Mucormycosis medications: a patent review

M Imran, A AS, M Tauseef, SA Khan… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction Mucormycosis is an uncommon but life-threatening infection with nonspecific
clinical manifestations that make its diagnosis/treatment difficult. The current literature …

Breaking the mold: a review of mucormycosis and current pharmacological treatment options

TT Riley, CA Muzny, E Swiatlo… - Annals of …, 2016 - journals.sagepub.com
Objective: To review the current literature for the pathogenesis of mucormycosis, discuss
diagnostic strategies, and evaluate the efficacy of polyenes, triazoles, and echinocandins as …