Subunit vaccine formulations often include adjuvants that primarily stimulate innate immune
cells. While young infants represent the major target population for vaccination, effective …

The success of the World Health Organization recommended “Expanded Program of
Immunization”(EPI) and similar regional or national programs has been astounding …

Molecular characterization of mechanisms by which human pattern recognition receptors
(PRRs) detect danger signals has greatly expanded our understanding of the innate …

Introduction: Neonates are less responsive to vaccines than adults, making it harder to
protect newborns against infection. Neonatal differences in antigen-presenting cell, B and T …

Vaccines were first introduced more than 200 years ago and have since played a key role in
the reduction of morbidity and mortality caused by infectious diseases. Many of the safest …

The purpose of this review is to provide a general overview of adjuvants as immune
potentiators, and to offer new insights into the immunological basis and molecular …

Toward precision adjuvants: optimizing science and safety : Current Opinion in Pediatrics
Toward precision adjuvants: optimizing science and safety : Current Opinion in Pediatrics Log …

The neonatal phase is a transitory period characterized by an absence of memory cells,
favoring a slow adaptive response prone to tolerance effects and the development of Th2 …

Adjuvants are substances that boost the immunogenicity of vaccines. However, most
successful vaccines have been derived empirically and are capable of inducing robust T …

Immunisation of the newborn represents a key global strategy in overcoming morbidity and
mortality due to infection in early life. Potential limitations, however, include poor …