NovoLign: metaproteomics by sequence alignment

H Kleikamp, R van der Zwaan, R van Valderen… - bioRxiv, 2024 - biorxiv.org
Tremendous advances in mass spectrometric and bioinformatic approaches have expanded
proteomics into the field of microbial ecology. The commonly used spectral annotation …

Database-independent de novo metaproteomics of complex microbial communities

HBC Kleikamp, M Pronk, C Tugui, LG da Silva… - Cell Systems, 2021 - cell.com
Metaproteomics has emerged as one of the most promising approaches for determining the
composition and metabolic functions of complete microbial communities. Conventional …

Quantitative profiling of microbial communities by de novo metaproteomics

HBC Kleikamp, M Pronk, C Tugui, LG da Silva… - bioRxiv, 2020 - biorxiv.org
Metaproteomics has emerged as one of the most promising approaches for determining the
composition and metabolic functions of complete microbial communities. Conventional …

MetaX: A peptide centric metaproteomic data analysis platform using Operational Taxa-Functions (OTF)

Q Wu, Z Ning, A Zhang, X Zhang, Z Sun, D Figeys - bioRxiv, 2024 - biorxiv.org
Metaproteomics analyzes the functional dynamics of microbial communities by identifying
peptides and mapping them to the most likely proteins and taxa. The challenge in this field …

mPies: a novel metaproteomics tool for the creation of relevant protein databases and automatized protein annotation

J Werner, A Géron, J Kerssemakers… - Biology Direct, 2019 - Springer
Metaproteomics allows to decipher the structure and functionality of microbial communities.
Despite its rapid development, crucial steps such as the creation of standardized protein …

Metaproteomics: sample preparation and methodological considerations

BJ Kunath, G Minniti, M Skaugen, LH Hagen… - … sample treatments in …, 2019 - Springer
Meta-omic techniques have progressed rapidly in the past decade and are frequently used
in microbial ecology to study microorganisms in their natural ecosystems independent from …

Improving the quality of genome, protein sequence, and taxonomy databases: A prerequisite for microbiome meta‐omics 2.0

O Pible, J Armengaud - Proteomics, 2015 - Wiley Online Library
High‐throughput shotgun metaproteomic approaches on environmental or medical
microbiomes are producing huge amounts of tandem mass spectrometry data. These can be …

metaExpertPro: a computational workflow for metaproteomics spectral library construction and data-independent acquisition mass spectrometry data analysis

Y Sun, Z Xing, S Liang, Z Miao, L Zhuo, W Jiang… - bioRxiv, 2023 - biorxiv.org
Background: Analysis of mass spectrometry-based metaproteomic data, in particular large-
scale data-independent acquisition MS (DIA-MS) data, remains a computational challenge …

MetaProClust-MS1: A tool for clustering metaproteomes using rapid MS1 profiling

CMA Simopoulos, Z Ning, L Li, MM Khamis, X Zhang… - bioRxiv, 2021 - biorxiv.org
Metaproteomics is used to explore the composition, dynamics and function of microbial
communities. How-ever, acquiring data by tandem mass spectrometry is time consuming …

metaQuantome: an integrated, quantitative metaproteomics approach reveals connections between taxonomy and protein function in complex microbiomes

CW Easterly, R Sajulga, S Mehta, J Johnson… - Molecular & Cellular …, 2019 - ASBMB
Microbiome research offers promising insights into the impact of microorganisms on
biological systems. Metaproteomics, the study of microbial proteins at the community level …