Background There is no criterion reference for assessing healthy ageing and this creates
difficulties when conducting and comparing research on ageing across studies. A cardinal …

Sensitive and specific biomarkers of ageing are needed to evaluate interventions to extend
health span. However, there is growing evidence that information provided by candidate …

Background and objective As the proportion of aging people in our population increases
steadily, global strategies accompanied by extensive research are necessary to tackle …

With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …

Individuals of the same age may not age at the same rate. Quantitative biomarkers of aging
are valuable tools to measure physiological age, assess the extent of 'healthy aging', and …

The aging process has been linked to the occurrence of chronic diseases and functional
impairments, including cancer, sarcopenia, frailty, metabolic, cardiovascular, and …

Background Chronological age is the strongest risk factor for most chronic diseases.
Developing a biomarker-based age and understanding its most important contributing …

Background Healthy ageing frameworks have been highly explored. Our objective was to
assess existing frameworks for healthy ageing and to identify commonly described factors …

Much progress has been made in the past decades in unraveling the mechanisms that are
responsible for aging. The discovery that particular gene mutations in experimental species …

A most challenging task for scientists that are involved in the study of ageing is the
development of a measure to quantify health status across populations and over time. In the …