Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration
… in vivo pushed cells towards adaptive repair and ameliorates fibrosis. … summary, our
single-cell analysis defines key differences in adaptive and fibrotic repair and identifies druggable …
single-cell analysis defines key differences in adaptive and fibrotic repair and identifies druggable …
Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line
… unique druggable susceptibilities, thus updating the paradigm of adaptive resistance … -High
cell subpopulations, which tend to take different paths to develop drug tolerance. Thus, it is …
cell subpopulations, which tend to take different paths to develop drug tolerance. Thus, it is …
Identification of resistance pathways and therapeutic targets in relapsed multiple myeloma patients through single-cell sequencing
… In prespecified exploratory analyses, comparison of 41 … Trials comparing the heterogeneity
and druggable pathways … patients, including hypoxia adaptation, protein folding and …
and druggable pathways … patients, including hypoxia adaptation, protein folding and …
Mechanistic models of signaling pathways deconvolute the glioblastoma single-cell functional landscape
… reveals a complex functional landscape at single-cell level. Different clusters of neoplastic …
may confer tumors different aggressiveness and invasion abilities, highlighting the relevance …
may confer tumors different aggressiveness and invasion abilities, highlighting the relevance …
[HTML][HTML] scRank infers drug-responsive cell types from untreated scRNA-seq data using a target-perturbed gene regulatory network
… of drug-responsive cell types using untreated single-cell data, thus providing … different cell
types exhibit changes in cellular states upon exposure to a drug. A common means of analysis …
types exhibit changes in cellular states upon exposure to a drug. A common means of analysis …
Single-cell analyses reveal increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer
CA Stewart, CM Gay, Y Xi, S Sivajothi… - Nature cancer, 2020 - nature.com
… identifying pathways associated with resistance that are druggable … of adaptive resistance
to these agents, but highlights how the … Additional efforts could compare single-cell data from …
to these agents, but highlights how the … Additional efforts could compare single-cell data from …
[PDF][PDF] Single-cell phosphoproteomics resolves adaptive signaling dynamics and informs targeted combination therapy in glioblastoma
… along druggable pathways, but drugs targeted to those pathways … genomics and single-cell
phosphoproteomics analyses of a … to compare and confirm the single-cell IHC data using the …
phosphoproteomics analyses of a … to compare and confirm the single-cell IHC data using the …
Trajectories from Snapshots: Integrated proteomic and metabolic single-cell assays reveal multiple independent adaptive responses to drug tolerance in a BRAF …
… independently druggable. Our results update the paradigm of … the single-cell data from all
time points into 14 different sub-… per pathway selected to quantify with single-cell barcode …
time points into 14 different sub-… per pathway selected to quantify with single-cell barcode …
Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance
SG Danielli, E Porpiglia, AJ De Micheli, N Navarro… - Science …, 2023 - science.org
… , highlighting their role as emerging hallmarks of cancer (4). … While some eRMS tumors
harbor druggable genetic … We confirmed these differences in a large RMS patient mRNA …
harbor druggable genetic … We confirmed these differences in a large RMS patient mRNA …
Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma
… as druggable targets, according to previous findings that drug responses can be widely different
… the heterogeneous drug target pathway activations at the single-cell level in a refractory …
… the heterogeneous drug target pathway activations at the single-cell level in a refractory …