In Vivo and Ex Vivo Pediatric Brain Tumor Models: An Overview

Z Li, SA Langhans - Frontiers in oncology, 2021 - frontiersin.org
… In the past, the diagnosis and classification of brain tumors … used as platforms for human
brain tumor cells, or tumors can be … mimic the physiological function of brain, challenges remain. …

Ex Vivo Tumor Culture Systems for Functional Drug Testing and Therapy Response Prediction

TG Meijer, KAT Naipal, A Jager, DC van Gent - Future science OA, 2017 - Taylor & Francis
… of personalized medicine. Prediction of individual treatment responses by functional ex vivo
… tool, since their generation takes several weeks and clinical diagnostic testing for individual …

Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine

C Pauli, BD Hopkins, D Prandi, R Shaw, T Fedrizzi… - Cancer discovery, 2017 - AACR
… a robust precision cancer care platform that integrates whole-… , stored in our living biobank,
and used for functional studies. … , and colorectal cancers, we also consider the ex vivo culture …

Nondestructive tissue analysis for ex vivo and in vivo cancer diagnosis using a handheld mass spectrometry system

J Zhang, J Rector, JQ Lin, JH Young, M Sans… - Science translational …, 2017 - science.org
… Emerging optical technologies including Raman spectroscopy and stimulated Raman
scattering microscopy have been recently applied for intraoperative diagnosis of brain cancers (12…

Ex vivo ultrasonic samples of human brain tumors in the molecular era

AJ Kirby, JP Lavrador, I Bodi, F Vergani… - Neuro-oncology …, 2020 - academic.oup.com
… They offer a viable platform to characterize heterogeneity … that is relevant to diagnosis
and treatment. We propose that … The linear regression function was used to fit lines to data. …

A Simple Three-dimensional Hydrogel Platform Enables Ex Vivo Cell Culture of Patient and PDX Tumors for Assaying Their Response to Clinically Relevant …

KC Hribar, CJ Wheeler, A Bazarov, K Varshneya… - Molecular cancer …, 2019 - AACR
personalized medicine. Here, we present a novel three-dimensional (3D) ECM hydrogel
system, VersaGel, for assaying ex vivo … drug screening and personalized diagnostics. This study …

Precision oncology using ex vivo technology: a step towards individualised cancer care?

ST Williams, G Wells, S Conroy, H Gagg… - Expert Reviews in …, 2022 - cambridge.org
… drug discovery platforms, such as ex vivo approaches. … of personalised therapy is to integrate
functional phenotypic … Moving forward into a diagnostic environment ex vivo screening …

Bioprinting of in vitro tumor models for personalized cancer treatment: a review

S Mao, Y Pang, T Liu, Y Shao, J He, H Yang… - …, 2020 - iopscience.iop.org
… to construct complex 3D functional living cell structures [67]. … Patient-specific ex vivo models
of human tumors that … and detection system [123], which then provides a more powerful …

An ex vivo brain slice model to study and target breast cancer brain metastatic tumor growth

L Ciraku, RA Moeller, EM Esquea, WA Gocal… - JoVE (Journal of …, 2021 - jove.com
personalized to target an individual patient's breast cancer … a year after their brain-metastasis
diagnosis, and their quality … The live imaging represents tumor growth as a function of GFP …

Patient Derived Ex-Vivo Cancer Models in Drug Development, Personalized Medicine, and Radiotherapy

R Zitter, RM Chugh, S Saha - Cancers, 2022 - mdpi.com
… -physiological bioengineered platform have already been … functional homologous
recombination and PARPi sensitivity. Isolating mechanisms of chemosensitivity rapidly after …