… This review summarizes the regulatory mechanisms of Bmi-1 … Bmi-1 through the Akt pathway
to promote tumorigenesis [18]. It has … and the DNA damage response. The study found that …

… The known regulatory mechanisms of BMI1 in cancer … side effects of novel agents that
specifically target BMI1 for … , and the activation of DNA damage response (DDR) pathway; …

… that MYCN-induced BMI1 positively regulated NB cell proliferation … the role of BMI1 in the
DNA damage response pathway … been investigating the role of BMI1 in NB tumorigenesis. Cui …

… examined the DNA damage response and repair proteins as … cells, indicating BMI1′s
regulatory role in autophagy. The … This study was supported in part by grants received from an …

… cancer, BMI1 is required for K-Ras induced tumorigenesis in … in the regulation of the DNA
damage response (DDR). PRC1-… and side effects, HDAC inhibitor-mediated reduction of BMI1 …

… This review discusses the diverse mode of BMI1 regulation at … and consequently promotes
tumorigenesis by promoting cell … damage and in preventing DNA damage response pathways…

… BMI1 facilitates DNA damage response (DDR) induced by … for tumorigenesis [10, 11] and
upregulation of BMI1 occurs in … evidence of a role for BMI1 in DDR regulation by enhancing …

… suppressor genes regulate the key signaling pathways involved in tumorigenesis and
cancer … regulate specific cellular functions or influence the expression of a subset of MiRNAs. …

… a critical role in regulating self-renewal of normal and tumorigenic … However, only a
few studies have proposed implicated BMI-1 in … that a DNA repair enzyme, O6-methylguanine-DNA …

… in different aspects of DNA repair through regulation of ATM-… at the DNA lesions to play their
roles in HR, DNA repair capability, … Collectively, overexpression of both NF-YA and BMI-1 is …