A pan-tissue DNA-methylation epigenetic clock based on deep learning

LP de Lima Camillo, LR Lapierre, R Singh - npj Aging, 2022 - nature.com
… the vast majority based on … epigenetic clocks using deep learning. First, we gathered 142
publicly available data sets from several human tissues to develop AltumAge, a neural network

A pan-tissue DNA-methylation epigenetic clock based on deep learning

LR Lapierre, S Ritambhara - NPJ Aging and Mechanisms of …, 2022 - search.proquest.com
… the vast majority based on … epigenetic clocks using deep learning. First, we gathered 142
publicly available data sets from several human tissues to develop AltumAge, a neural network

AltumAge: A Pan-Tissue DNA-Methylation Epigenetic Clock Based on Deep Learning

LP de Lima Camillo, LR Lapierre, R Singh - bioRxiv, 2021 - biorxiv.org
… the vast majority based on … epigenetic clocks using deep learning. First, we gathered 143
publicly available data sets from several human tissues to develop AltumAge, a neural network

Pan-tissue methylation aging clock: recalibrated and a method to analyze and interpret the selected features

KA Vijayakumar, G Cho - Mechanisms of Ageing and Development, 2022 - Elsevier
machine learning model to find out the biological meaning behind these DNA methylation
age … In this study, we have designed an epigenetic clock using the DNA methylation levels of …

A revised multi-tissue, multi-platform epigenetic clock model for methylation array data

OA Pipek, I Csabai - Journal of Mathematical Chemistry, 2023 - Springer
age and correlations between “DNA methylation age” and … epigenetic age predictors, the
Horvath pan-tissue epigenetic … is an expected characteristic of any machine learning approach. …

Biologically informed deep learning for explainable epigenetic clocks

A Prosz, O Pipek, J Börcsök, G Palla, Z Szallasi… - Scientific Reports, 2024 - nature.com
age predictors called epigenetic clocks can accurately estimate the biological age of an
individual based on cellular DNA methylation, … Similarly to the analysis of the pan-tissue cohort, …

Application of a mathematical model to clarify the statistical characteristics of a pan-tissue DNA methylation clock

D Okada - GeroScience, 2024 - Springer
epigenetic age and chronological age. It is considered that the pan-tissue DNA methylation
clock … bulk data, allowing robust aging prediction based on accumulated genomic stress. …

MSCAP: DNA Methylation Age Predictor based on Multiscale Convolutional Neural Network

H Wang, R Cai, X Zong, Z He… - 2023 IEEE International …, 2023 - ieeexplore.ieee.org
… To better construct a pan-tissue epigenetic clock with high prediction accuracy, the datasets
… with existing epigenetic clocks developed based on elastic network and other deep learning

Epigenetic age prediction

DJ Simpson, T Chandra - Aging cell, 2021 - Wiley Online Library
… of age predictors utilising DNA methylation have been developed, referred to as epigenetic
clocks. … The first multi-tissue age predictor (referred to as the Horvath or Pan-Tissue clock) …

Accurate age prediction from blood using a small set of DNA methylation sites and a cohort-based machine learning algorithm

M Varshavsky, G Harari, B Glaser, Y Dor, R Shemer… - Cell Reports …, 2023 - cell.com
… Here, we present a compact epigenetic clock for blood, which outperforms state-of… clock to
sequencing-based data, with far-reaching implications for a better understanding of epigenetic