Toward personalized computer simulation of breast cancer treatment: A multiscale pharmacokinetic and pharmacodynamic model informed by multitype patient data
… tissue to a combination of chemotherapeutic and … We account for spatiotemporal heterogeneity
in the simulated tissue … to build models that allow the simulation of other solid tumors. This …
in the simulated tissue … to build models that allow the simulation of other solid tumors. This …
A mathematical model to estimate chemotherapy concentration at the tumor-site and predict therapy response in colorectal cancer patients with liver metastases
… outcome, and thus our mathematical modeling approach can be … patients with solid tumors
who present with de novo … to help guide individualized patient care by estimating tumor site …
who present with de novo … to help guide individualized patient care by estimating tumor site …
A computational multiscale agent-based model for simulating spatio-temporal tumour immune response to PD1 and PDL1 inhibition
… , such as radiotherapy, chemotherapy and other immunotherapies including … model (see
Material and methods section for details). We simulated tumour development in patients …
Material and methods section for details). We simulated tumour development in patients …
Blackboard to bedside: a mathematical modeling bottom-up approach toward personalized cancer treatments
… models of solid tumors, combined with patient-specific tumor … 46 capable of simulating
spatiotemporal tumor dynamics … investigated tumor growth and chemotherapy response of a tumor …
spatiotemporal tumor dynamics … investigated tumor growth and chemotherapy response of a tumor …
Simulations of tumor growth and response to immunotherapy by coupling a spatial agent-based model with a whole-patient quantitative systems pharmacology model
… and biological aspects of modeling cancer. First, the coupling … of the tumor microenvironment
on solid tumor growth and … spatial and temporal comparisons of the immune response …
on solid tumor growth and … spatial and temporal comparisons of the immune response …
[HTML][HTML] … with a spatial quantitative systems pharmacology model spQSP for personalized prediction of triple-negative breast cancer immunotherapy response
… -based models (ABM) to simulate spatiotemporal tumor progression and simulation results
… Then, we simulate tumor progressions for all four virtual patient cohorts receiving nivolumab …
… Then, we simulate tumor progressions for all four virtual patient cohorts receiving nivolumab …
Image-based spatio-temporal model of drug delivery in a heterogeneous vasculature of a solid tumor—Computational approach
… a helpful tool to evaluate the chemotherapy treatment schedules. In the … personalized
medicine to optimize patient-specific treatments. Also, such image-based modeling of solid tumors …
medicine to optimize patient-specific treatments. Also, such image-based modeling of solid tumors …
A mathematical model for predicting the spatiotemporal response of breast cancer cells treated with doxorubicin
… demonstrate that our spatiotemporal modeling approach can … individualized measurements
of tumor cell dynamics in the … cell populations before and after chemotherapy with high …
of tumor cell dynamics in the … cell populations before and after chemotherapy with high …
Cell-level spatio-temporal model for a Bacillus Calmette–Guérin-based immunotherapy treatment protocol of superficial bladder cancer
T Lazebnik - Cells, 2022 - mdpi.com
… simulation of the proposed model for … of patients do not react to the treatment [68], we
believe that healthcare professionals can use our model to provide a better, more personalized …
believe that healthcare professionals can use our model to provide a better, more personalized …
[HTML][HTML] Precision medicine with imprecise therapy: computational modeling for chemotherapy in breast cancer
… of cancer that allows us to compute the spatiotemporal … of the response of an individual
patient to an individualized … agents were given over a short course to treat solid tumors [36…
patient to an individualized … agents were given over a short course to treat solid tumors [36…