… receptor 1 silencing enhances advanced oxidative protein product-induced epithelial-to-mesenchymal transition of human kidney proximal tubular epithelial cells via …

H Feng, H Hu, P Zheng, T Xun, S Wu, X Yang… - Biochemical and …, 2020 - Elsevier
… reported to activate vascular endothelial cells through the receptor … regulated by AGER1
during AOPP-induced HKC-8 cell-EMT. … Oxidative stress is one of the initial pathogenic factors of …

PKCδ regulates the vascular biology in diabetic atherosclerosis

P Qin, C He, P Ye, Q Li, C Cai, Y Li - Cell Communication and Signaling, 2023 - Springer
… role of PKCδ in regulating the dysfunction of endothelial cells, … Diabetes is a potent oxidative
stress inducer. It has been … -product receptor 1 (AGER1) via EGFR/PKCδ pathway inhibition […

Rap1a overlaps the AGE/RAGE signaling cascade to alter expression of α-SMA, p-NF-κB, and p-PKC-ζ in cardiac fibroblasts isolated from type 2 diabetic mice

SD Burr, JA Stewart Jr - Cells, 2021 - mdpi.com
regulating oxidative stress [31,32]. In the cardiovascular system, Rap1a has been documented
to impact fibroblast migration and proliferation via … verified to impact oxidative stress by …

Glycation-associated diabetic nephropathy and the role of long noncoding RNAs

A Durge, I Sharma, RS Tupe - Biomedicines, 2022 - mdpi.com
… , AGER1 regulates NADPH oxidase-dependent oxidative stress by protein kinase C-δ (PKC-δ) …
By binding to Smad3, LncRNA Arid2-IR regulated levels of oxidative stress, inflammation, …

Does dietary fat affect advanced glycation end products and their receptors? A systematic review of clinical trials

NP Mendes, PVM Ribeiro, RCG Alfenas - Nutrition Reviews, 2022 - academic.oup.com
… expression of RAGE as well as increased expression of AGER1. … effects on the concentrations
of circulating AGEs and their receptors and, consequently, on the levels of oxidative stress

Rap1a regulates cardiac fibroblast contraction of 3D diabetic collagen matrices by increased activation of the AGE/RAGE cascade

SD Burr, JA Stewart Jr - Cells, 2021 - mdpi.com
… source of ECM collagen impacts cardiac fibroblast contractile … /RAGE-mediated increase in
oxidative stress and myofibroblast … vein endothelial cells and microvascular endothelial cells

Indole-linked 1, 2, 3-triazole derivatives efficiently modulate COX-2 protein and PGE2 levels in human THP-1 monocytes by suppressing AGE-ROS-NF-kβ nexus

H Jahan, NN Siddiqui, S Iqbal, FZ Basha, MA Khan… - Life Sciences, 2022 - Elsevier
… Hyperglycemic milieu in diabetes increases oxidative stress … This causes impairment of
endothelial cells and activation of … In addition to compounds 12, and 13 anti-oxidative effect, our …

[HTML][HTML] Stochastic non-enzymatic modification of long-lived macromolecules-A missing hallmark of aging

A Fedintsev, A Moskalev - Ageing research reviews, 2020 - Elsevier
… that the cellular fitness of OPCs is predominantly regulated not … PIEZO1, since its inhibition
blocked the effects of stiff ECM. … (MT) dynamics: endothelial cells migrating on a stiff surface …

Suppression of COX-2/PGE2 levels by carbazole-linked triazoles via modulating methylglyoxal-AGEs and glucose-AGEs–induced ROS/NF-κB signaling in monocytes

H Jahan, NN Siddiqui, S Iqbal, FZ Basha, S Shaikh… - Cellular …, 2022 - Elsevier
… proteins exacerbate oxidative stress by generating ROS, resulting in pathophysiological
effects on … Regulation of tissue factor gene expression in monocytes and endothelial cells: …

Inhibition of PKC-delta expression using siRNAs restores coronary dilation in rats with streptozotocin-induced diabetes

A Khromov, N Dobrelya, I Strielkov… - Фармакологія та …, 2017 - irbis-nbuv.gov.ua
oxidase-dependent oxidant stress via PKC-δ: implications for vascular disease // American
Journal of Physiology – … PKC-δ gene silencing in diabetic rats using siRNAs had no …