Immune age and biological age as determinants of vaccine responsiveness among elderly populations: The Human Immunomics Initiative research program

J Goudsmit, AHJ van den Biggelaar… - European Journal of …, 2021 - Springer
… Central to our thinking is the idea that predictors of age-related non-communicable diseases
are … the potentiating or suppressing effect of antibodies on innate immune responses. At the …

Influence of immune aging on vaccine responses

CE Gustafson, C Kim, CM Weyand… - … and Clinical Immunology, 2020 - Elsevier
… basis to study age-related mediators of protective immunity. … pool of vaccine-responsive
cells to poor survival of vaccine-… and vaccinations and their functional consequences (orange …

Immunosenescence and human vaccine immune responses

SN Crooke, IG Ovsyannikova, GA Poland… - Immunity & …, 2019 - Springer
immunity to adaptive immune responses have become more appreciated in recent years [31],
we limit our discussion to age-related changes in the adaptive immuneresponsiveness of …

[HTML][HTML] Vaccination in the elderly: the challenge of immune changes with aging

A Ciabattini, C Nardini, F Santoro, P Garagnani… - … in immunology, 2018 - Elsevier
… of inflammaging in vaccination responsiveness to support … Age-related autonomous B
cell defects include a reduction in … therapy exerts positive effect on vaccine efficacy, but this …

Targeting inflammation and immunosenescence to improve vaccine responses in the elderly

B Pereira, XN Xu, AN Akbar - Frontiers in immunology, 2020 - frontiersin.org
… wider implications for immune responses to vaccination in … in the age-related hypo-responsiveness
to vaccination and … be a promising strategy to enhance vaccine responses (83). This …

Understanding immunosenescence and its impact on vaccination of older adults

JC Allen, FR Toapanta, W Chen, SM Tennant - Vaccine, 2020 - Elsevier
… of age-related changes that affect vaccine responsiveness; … -mediated immune responses,
current vaccination schedules … , its implications for vaccinating older adults, and vaccination

Age-associated alterations in immune function and inflammation

ED Lewis, D Wu, SN Meydani - Progress in Neuro-Psychopharmacology …, 2022 - Elsevier
… This review will focus on age-related changes in the immune system including
immunosenescence and inflammation as well as the functional consequences of these age-related

Changes in T cell homeostasis and vaccine responses in old age

GCL Wong, MC Strickland, A Larbi - Vaccines for Older Adults: Current …, 2020 - karger.com
… in the loss of vaccine responsiveness. This chapter examines … cells) may have implications
on vaccination performance in old … Furthermore, the agerelated reduction of haematopoietic …

Aging and influenza vaccine-induced immunity

HL Dugan, C Henry, PC Wilson - Cellular immunology, 2020 - Elsevier
vaccine responsiveness in the elderly can be attributed to immunosenescence, recent work
has shown that repeated influenza immunizations … repeated influenza immunizations on CD4 …

Aging, immunity, and COVID-19: how age influences the host immune response to coronavirus infections?

V Bajaj, N Gadi, AP Spihlman, SC Wu, CH Choi… - Frontiers in …, 2021 - frontiersin.org
immune response to vaccines are influenced by age-related … immunological correlates and
consequences of COVID-19 … contribute to decreased responsiveness to immunization, and …