… of DNA sensing through the cGAS–STING pathway, describing how the cytoplasmic cGAS
… plethora of regulatory mechanisms that keep this pathway in check. We also discuss how …

… that AKT can phosphorylate hcGAS S305 as CDK1 does 23 . Our results indicated that the
AKT inhibitor … Why AKT does not contribute to this phosphorylation in mitotic cells is unknown. …

… the cGAS pathway and other pathways that regulate Akt. … or immune-system-checkpoint
inhibitors (such as antibodies to … that the cGAS–STING pathway is important for the sensing of …

… (cGAS) is a DNA sensor that detects and binds to cytosolic … modifications: AKT and BLK
phosphorylate cGAS; TTLL4/… to and decreased efficacy of immune checkpoint blockers. A recent …

… cGAS was first discovered as the cytosolic DNA sensor that … cGAS at the plasma membrane
to avoid self-DNA detection … Unlike AKT, CDK1 only phosphorylates the S291 site of cGAS …

… DNA sensing in mitotic cells [39]. Thus, it is plausible that AKT, CDK1, and AKB govern cGAS
… -STING, through mtDNA and/or dsDNA, in cancer cells may serve as a checkpoint to the …

… The cyclic GMP-AMP synthase (cGAS) protein is a pattern-recognition receptor of the … as
a main cytosolic sensor of pathogenic or damaged DNA. cGAS DNA binding initiates catalytic …

… of cGAS by DNA-PK functions as a checkpoint to maintain immune homeostasis. …
Combining with our findings, we propose that DNA-PK functions for DNA sensing in cells …

… -DNA detection, such as restriction of DNA or cGAS activity … For example, cGAS is
phosphorylated by AKT at S305 after … a potent strategy against immune checkpoint …

… The potential impact of cGAS-STING pathway in hepatic … In this review, the relationship
between cGAS-STING pathway … agonists and antagonists of cGAS-STING signaling as novel …