[HTML][HTML] The molecular mechanisms of EpCAM in regulating tumor progression and development of anti-EpCAM antibodies for colon cancer diagnosis and therapy
HC Wu, KH Liang, HP Hsieh, WS Li - Annals of Oncology, 2019 - Elsevier
… We also demonstrated that treatment with an anti-EpCAM neutralizing antibody, EpAb2-6, …
Importantly, we also showed that EpAb2-6 inhibited the nuclear translocation of EpICD and …
Importantly, we also showed that EpAb2-6 inhibited the nuclear translocation of EpICD and …
Epithelial cell adhesion molecule (EpCAM) regulates HGFR signaling to promote colon cancer progression and metastasis
CC Lee, CJ Yu, SS Panda, KC Chen, KH Liang… - Journal of Translational …, 2023 - Springer
… treatment of an anti-EpCAM neutralizing antibody (EpAb2-6) and an HGFR inhibitor (crizotinib)
significantly inhibits tumor … in metastatic and orthotopic animal models of colon cancer. …
significantly inhibits tumor … in metastatic and orthotopic animal models of colon cancer. …
Extracellular domain of EpCAM enhances tumor progression through EGFR signaling in colon cancer cells
KH Liang, HC Tso, SH Hung, II Kuan, JK Lai, FY Ke… - Cancer letters, 2018 - Elsevier
… so, we generated EpAb2-6, a novel monoclonal antibody that … EpAb2-6 and EpAb3-5 are
anti-EpCAM antibodies, which … We further found that EpAb2-6 treatment also reduced nuclear …
anti-EpCAM antibodies, which … We further found that EpAb2-6 treatment also reduced nuclear …
The anti‑epithelial cell adhesion molecule (EpCAM) monoclonal antibody EpMab‑16 exerts antitumor activity in a mouse model of colorectal adenocarcinoma
H Hosono, T Ohishi, J Takei, T Asano… - Oncology …, 2020 - spandidos-publications.com
… an anti‑EpCAM monoclonal antibody (mAb) for targeting … a novel anti-EpCAM mAb may be
useful for treating colorectal … xenograft model, they demonstrated that EpAb2-6 induced CRC …
useful for treating colorectal … xenograft model, they demonstrated that EpAb2-6 induced CRC …
EpCAM signaling promotes tumor progression and protein stability of PD-L1 through the EGFR pathway
HN Chen, KH Liang, JK Lai, CH Lan, MY Liao… - Cancer research, 2020 - AACR
… model of metastatic colon carcinoma to test whether EpAb2-6 treatment could increase the
… We have previously demonstrated that anti-EpCAM neutralizing antibody, EpAb2-6, could …
… We have previously demonstrated that anti-EpCAM neutralizing antibody, EpAb2-6, could …
Intracellular domain of epithelial cell adhesion molecule induces Wnt receptor transcription to promote colorectal cancer progression
SS Panda, CC Lee, K Geevimaan, KC Chen… - Journal of Biomedical …, 2024 - Springer
… Our humanized anti-EpCAM antibody hEpAb2-6 blocks these … As such, the EpCAM-neutralizing
antibody, EpAb2-6, was … anti-EpCAM therapeutics may be effective for the treatment …
antibody, EpAb2-6, was … anti-EpCAM therapeutics may be effective for the treatment …
Characterization of human anti-EpCAM antibodies for developing an antibody–drug conjugate
H Satofuka, Y Wang, K Yamazaki, S Hamamichi… - Scientific Reports, 2023 - nature.com
… EpAb2-6—a mouse antibody—is the first antibody class … mAbs, and it has been approved
for the treatment of malignant … cytotoxicity against the human colon cancer cell line HCT116, …
for the treatment of malignant … cytotoxicity against the human colon cancer cell line HCT116, …
Concise review: aggressive colorectal cancer: role of epithelial cell adhesion molecule in cancer stem cells and epithelial-to-mesenchymal transition
M Boesch, G Spizzo, A Seeber - Stem cells translational …, 2018 - academic.oup.com
… The first anti-EpCAM antibody that has received approval for cancer treatment from the …
EpAb2–6 binds to an epitope localized in the TY loop that is very close to the cleavage site …
EpAb2–6 binds to an epitope localized in the TY loop that is very close to the cleavage site …
Production of novel recombinant anti-EpCAM antibody as targeted therapy for breast cancer
… against the EpCAM molecule, called Edrecolomab with the Panorex brand, is a mouse
IgG2a type used to treat colon cancer. However, it had a series of disadvantages (abdominal …
IgG2a type used to treat colon cancer. However, it had a series of disadvantages (abdominal …
[PDF][PDF] Site-Specific Antibody Modification and Immobilization on a Microfluidic Chip to Promote Capture of Circulating Tumor Cells and Microemboli
R biotinyl anti-EpCAM - academia.edu
… The primary antibodies rabbit anti-human CK-20 (for colon cancer patients, Abcam, dilution
… C., An anti-EpCAM antibody EpAb2-6 for the treatment of colon cancer. Oncotarget 2015, 6, …
… C., An anti-EpCAM antibody EpAb2-6 for the treatment of colon cancer. Oncotarget 2015, 6, …