[HTML][HTML] An examination of polygenic score risk prediction in individuals with first-episode psychosis
Abstract Background Polygenic risk scores (PRSs) have successfully summarized genome-
wide effects of genetic variants in schizophrenia with significant predictive power. In a
clinical sample of first-episode psychosis (FEP) patients, we estimated the ability of PRSs to
discriminate case-control status and to predict the development of schizophrenia as
opposed to other psychoses. Methods The sample (445 case and 265 control subjects) was
genotyped on the Illumina HumanCore Exome BeadChip with an additional 828 control …
wide effects of genetic variants in schizophrenia with significant predictive power. In a
clinical sample of first-episode psychosis (FEP) patients, we estimated the ability of PRSs to
discriminate case-control status and to predict the development of schizophrenia as
opposed to other psychoses. Methods The sample (445 case and 265 control subjects) was
genotyped on the Illumina HumanCore Exome BeadChip with an additional 828 control …
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