… Activated HRAS induces the invasive phenotype in breast … ) cooperates with HRAS to induce
metastatic breast cancer (61)… in metastatic progression and poor clinical outcome of luminal …

… BMI1 overexpression induces epithelial to mesenchymal transition (EMT) and enhances
the … In breast cancer, Ki-67overexpression indicates an aggressive tumor and predicts poor …

… We propose a novel function of protein BMI1 to explain how breast cancer cells … BMI1
cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases. …

… breast cancer [5], colon carcinoma [6], non-small cell lung … In Bmi1/Ras-induced mouse HCC,
Bmi1 was highly expressed … into an invasive phenotype, and metastatic dissemination [25]. …

… on breast cancer cell invasion is achieved by inducing … that Bmi1 works with HRas in
MCF-10A cells to aggressively … , CK2α and Bmi1 cooperated to increase ovarian cancer cell …

… development in head and neck cancer patients and cooperates … of BMI1 together with H-Ras
did induce an aggressive and metastatic phenotype, with the unusual occurrence of breast …

… cascade which induces aggressive phenotypes in TNBC cells. … complex proteins, such as
BMI1 and suppressor of zeste 12 … sarcoma viral oncogene homologue (H-RAS) and the high …

… Metastatic in vivo models of breast cancer additionally demonstrate that BMI1 collaborates
with H-RAS … we took two approaches to rescue the phenotype of BMI1 inhibition. First, in Rh28 …

… Bmil cooperates with Kras to drive tumor growth in the lung .............................................. 78
Kinetics of BMI1 … many of the severe phenotypes associated with the BMI1 null mice, particularly …

… Specifically, activated forms of PIK3CA and H-RAS are able to … In summary, there are
many pathways that can induce EMT, … of p63 contributes to epithelial phenotypes, and affects …