… In summary, by performing a comprehensive analysis over 11 … robust single-cell potency measures, revealing that their robustness is driven by a correlation between mRNA expression …
… on single-cell transcriptomic data that conforms with the Waddington’s epigeneticlandscape … studies reconstructed the epigeneticlandscape from single-cellgeneexpressiondata using …
… epigeneticlandscape and genetic programmes in the light of recent advances in genomics and, specifically, single-cell … does not only lie in their potential to reveal structures within …
… Dynamical systems modeling has revealed the complexity of the regulation of … genes constitute a kinetic model which can be calibrated by learning from single-cellgeneexpressiondata…
… In summary, by studying the dynamic changes of expression covariation entropy, DICE can … primed states and bifurcation dynamics without the need for single-cell epigenomic data. …
MA Coomer, L Ham, MPH Stumpf - Cell Systems, 2022 - cell.com
… Summary The Waddington epigeneticlandscape has become an iconic representation of … Recent single-cell transcriptomic data provide new opportunities for quantifying this originally …
… Recent single-cell transcriptomic data provide new … , which shows the fixed points of the deterministic landscape U(x) … not be amenable to the bifurcationanalysis presented above. The …
NP Gao, O Gandrillon, A Páldi, U Herbach… - …, 2023 - ncbi.nlm.nih.gov
… Although the epigeneticlandscape was originally proposed only as … epigeneticlandscape the valley naturally widens around the branching point in the cell lineage, our analysisshows …
B Kaity, R Sarkar, B Chakrabarti, MK Mitra - Scientific reports, 2018 - nature.com
… epigeneticlandscape which represent the two differentiated states. A comprehensive phase space and bifurcationanalysis … Since the bifurcation diagram shows two distinct dynamical …