(NAD+) as a co-substrate in their enzymatic reactions. There are seven proteins (SIRT1-7) in
the human sirtuin family, among which SIRT1 is the most conserved and characterized.
SIRT1 in the brain, in particular, within the hypothalamus, plays crucial roles in regulating
systemic energy homeostasis and circadian rhythm. Apart from this, SIRT1 has also been
found to mediate beneficial effects in neurological diseases. In this review, we will first …