COVID19 is an emergent disease of aging

D Santesmasses, JP Castro, AA Zenin… - Aging cell, 2020 - Wiley Online Library
… establish COVID-19 as an emergent disease of aging, and age and age-related diseases as
its … , we propose that COVID-19, and more generally deadly respiratory diseases, should be …

[HTML][HTML] From causes of aging to death from COVID-19

MV Blagosklonny - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
COVID-19 are proportional to chances to die from aging itself at any age. The only discrepancy
between natural and COVID-19 … Whereas natural death rate is relatively high, COVID-19

[HTML][HTML] Why does COVID-19 disproportionately affect older people?

AL Mueller, MS McNamara, DA Sinclair - Aging (albany NY), 2020 - ncbi.nlm.nih.gov
aging to the pathogenesis of viruses. In this perspective, we offer potential mechanistic
explanations as to why COVID-19 … The resulting vascular inflammation is emerging as the cause …

Aging in COVID-19: Vulnerability, immunity and intervention

Y Chen, SL Klein, BT Garibaldi, H Li, C Wu… - Ageing research …, 2021 - Elsevier
… vulnerability to severe COVID-19 outcomes in … disease heterogeneity and aging. Such
knowledge is critical not only for understanding of COVID-19 pathogenesis but also for COVID-19

COVID-19: a challenge to physiology of aging

AG Golubev - Frontiers in physiology, 2020 - frontiersin.org
… and challenges imposed by COVID-19. However, the … of COVID-19 and the prevalent
aging-associated diseases. To achieve a proper balance in public health approaches to COVID-19, …

Role of senescence and aging in SARS-CoV-2 infection and COVID-19 disease

SM Lynch, G Guo, DS Gibson, AJ Bjourson, TS Rai - Cells, 2021 - mdpi.com
condition. As postulated throughout this review, we propose that senescence-aging-COVID-19
the world which support the hypothesis that COVID-19 is an emergent disease of aging. …

The dilemma of coronavirus disease 2019, aging, and cardiovascular disease: insights from cardiovascular aging science

M AlGhatrif, O Cingolani, EG Lakatta - JAMA cardiology, 2020 - jamanetwork.com
… of COVID-19, manifesting with greater disease severity. … We hypothesize that with
superimposed COVID-19 disease, … subpopulations to greater COVID-19 disease severity and …

COVID-19, neuropathology, and aging: SARS-CoV-2 neurological infection, mechanism, and associated complications

RS Kalra, JK Dhanjal, AS Meena, VC Kalel… - Frontiers in Aging …, 2021 - frontiersin.org
… Since the elderly population gradually develops neurological disorders with aging, COVID-19
… We have also shed light on the emerging artificial intelligence (AI) and machine learning …

[HTML][HTML] COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?

C Sargiacomo, F Sotgia, MP Lisanti - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
COVID-19, also known as SARS-CoV-2, is a new emergingCOVID-19 corona virus
preferentially targets senescent lung cells, resulting in increased morbidity and mortality in the aging

Severe COVID-19 and aging: are monocytes the key?

BD Pence - Geroscience, 2020 - Springer
… Here, I review emerging evidence to argue that … in COVID-19. I also describe changes
in monocyte function and phenotype that are characteristic of both aging and severe COVID-19, …