… functions, thereby increasing survival and maintaining reproductive … that CR induces SIRT1
expression in rat and human cells in … Histone deacetylation by SIRT1 promotes DNMT3B …

… metabolism due to the lack of SIRT1 deacetylase (13). In transgenic … However, overexpression
of SIRT1 enhances glucose … of SIRT1 or the SIRT1 activator in the CR mice can induce the …

… in mammals … has promoted the emergence of caloric restriction mimetics (CRMs). We
define CRMs as compounds that ignite the protective pathways of caloric restriction by promoting …

… 7 mammalian isoforms, which localize in the nucleus (SIRT1, … maintains a heterochromatic
environment by deacetylation of … + concentration in CR and induce several changes within the …

… causing reduced IGF-1 signaling are beneficial for survival in … is the deacetylation of FoxO1
and PGC-1α by Sirt1 in the liver … of FoxO3 as a key mechanism that promotes mitochondrial …

… SIRT1 NAD-dependent histone deacetylase, which is involved in the chromatin silencing
pathway, as the key regulator of life- and health-span extension induced … with mammalian cells, …

… , induced a decrease in the deacetylation levels of SIRT1 … mutant ataxin-3 clearance and to
do this its deacetylase … is disrupted (here promoted by ATG5 genetic silencing), SIRT1 is not …

… We demonstrated that CR also promotes HSF1 deacetylation through SIRT1 in the
hippocampus, ameliorating neurotoxicity induced by anesthesia and surgery in the vulnerable brain …

… how these events can interfere with the induction of cellular senescence. We discuss the …
ie SIRT1, SIRT3 and SIRT6) improves metabolic homeostasis through histone deacetylation…

… that permits a higher survival against adversity. This has … CR in cells may induce the activity
of the cytosolic SIRT1 and … of autophagy by deacetylation of FOXO3, promotes the renovation …