Human papillomavirus genome integration and head and neck cancer

LM Pinatti, HM Walline… - Journal of dental …, 2018 - journals.sagepub.com
… of human papillomavirus (HPV) integration into the hostHPV infection that leads to carcinoma
is characterized by high … of HPV, E7 binds to the pocket of RB, disrupting the interaction

Human papillomavirus integration strictly correlates with global genome instability in head and neck cancer

B Labarge, M Hennessy, L Zhang, D Goldrich… - Molecular Cancer …, 2022 - AACR
… that episomal HPV is captured in the host genome following … E6 and E7 appear to enhance
mutation frequency in primary … On the basis of our analysis of the various rearrangements and …

Human papilloma virus integration sites and genomic signatures in head and neck squamous cell carcinoma

J Mainguené, S Vacher, M Kamal, A Hamza… - Molecular …, 2022 - Wiley Online Library
… More recently, the interaction of the HPV genome with cancer-… in 49 patients with HPV positive
head and neck carcinoma. The … [20]; therefore, we performed gene expression analysis on …

Current status of human papillomavirus-related head and neck cancer: from viral genome to patient care

H Dong, X Shu, Q Xu, C Zhu, AM Kaufmann, ZM Zheng… - Virologica Sinica, 2021 - Springer
primary OPSCC and a second primary of any head and neckHPV-driven oncogenic processes
are characterized by HPV … studies on HPV virus-host protein interactions have identified …

Human papillomavirus genome variants and head and neck cancers: a perspective

JD Combes, S Franceschi - Infectious Agents and Cancer, 2018 - Springer
HPV types are powerful human carcinogens and the primary … -characteristics should be
considered in HPV variant studies … 60%) suggests a different host-viral interaction in the two sites. …

Genomic and transcriptomic characterization links cell lines with aggressive head and neck cancers

H Cheng, X Yang, H Si, AD Saleh, W Xiao, J Coupar… - Cell reports, 2018 - cell.com
… –q28 is a dominant genomic alteration found in all of the HPV(−) and HPV(+) HNSCC cell …
clustering analysis of fold changes in gene expression between HNSCC cell lines and primary

Influence of pathogens on host genome and epigenome in development of head and neck cancer

S Desai - Cancer Reports, 2023 - Wiley Online Library
HPV infection in oropharyngeal cancer. Systematic genomic analysis of the HNSCC tumours
… of microbes on other epigenetic interactions in head and neck cancer, there exist sparse …

[HTML][HTML] … of The Cancer Genome Atlas sequencing data reveals novel properties of the human papillomavirus 16 genome in head and neck squamous cell carcinoma

TJ Nulton, AL Olex, M Dozmorov, IM Morgan… - Oncotarget, 2017 - ncbi.nlm.nih.gov
… HPV16 genome in HPV-positive head and neck cancers (HNC). Raw RNA-Seq and Whole
… a protein-protein interaction [6, 7]. E1 interacts with components of the host DNA polymerase …

Subtypes of HPV-positive head and neck cancers are associated with HPV characteristics, copy number alterations, PIK3CA mutation, and pathway signatures

Y Zhang, LA Koneva, S Virani, AE Arthur, A Virani… - Clinical Cancer …, 2016 - AACR
… + HNC samples from two cohorts (84 total primary tumors), including 18 HPV − HNC … , the
integration of part or all of the HPV genome into the host genome is suggested to trigger focal …

Genomic insights into head and neck cancer

TN Beck, EA Golemis - Cancers of the head & neck, 2016 - Springer
… therapeutic opportunities in HPV- and HPV+ HNSCC based on the analysis of high … as a
result of HPV infection, and is a reliable proxy for positive HPV status in primary tumors of the …