β2 integrin CD11d/CD18: from expression to an emerging role in staged leukocyte migration

EN Blythe, LC Weaver, A Brown… - Frontiers in …, 2021 - frontiersin.org
… , the CD11/CD18 nomenclature will be used exclusively. … Finally, investigation within a
rat model demonstrated low … Both LAD I and III are characterized by impaired leukocyte

Not just an adhesion molecule: LFA-1 contact tunes the T lymphocyte program

NK Verma, D Kelleher - The journal of immunology, 2017 - journals.aai.org
… profile characterized by refractoriness to TGF-β (4). In addition, an inhibitory cross-talk between
… Signaling through the leukocyte integrin LFA-1 in T cells induces a transient activation of …

The expression of β2-integrins LFA-1 and MAC-1 on Blood Leucocytes and Kidneys of Patients with ANCA-associated Glomerulonephritis

M Yu, L Cheng, L Xue, Q Ren, Y Liang, L Ma, P Fu… - 2024 - researchsquare.com
LFA-1 and MAC-1 are composed of a different α subunit and … was to characterize the
expression of LFA-1 and MAC-1 both … the rat model of unilateral ureteral obstruction (UUO), LFA-1

A genetic model of constitutively active integrin CD11b/CD18

L Martinez, X Li, G Ramos-Echazabal… - The Journal of …, 2020 - journals.aai.org
… trunk were obtained for plaque characterization. Lesion size and … integrin subunits CD11b
and CD18, and of other α subunits (… function of the leukocyte adhesion molecules CD11/CD18. …

β2 Integrins—multi-functional leukocyte receptors in health and disease

M Bednarczyk, H Stege, S Grabbe, M Bros - International journal of …, 2020 - mdpi.com
… ) subunit and are specifically expressed by leukocytes. The α … is also characterized by a high
density of ICAM-1 on the APC … to prevent inflammation in hypoxia-induced lung injury in rats

The upregulation of integrin αDβ2 (CD11d/CD18) on inflammatory macrophages promotes macrophage retention in vascular lesions and development of …

MH Aziz, K Cui, M Das, KE Brown, CL Ardell… - The Journal of …, 2017 - journals.aai.org
… of β 2 integrins to leukocyte migration is fundamental. It has … (1:200 dilution of rat anti-mouse
Mac3 or 1:500 dilution of ratanalysis of α subunits, which are associated with β 2 integrin, …

Polymorphonuclear phenotypical expression of CD18, at baseline and after in vitro activation, in several clinical disorders: Revision of our case series

G Caimi, R Lo Presti, C Carollo… - Clinical …, 2023 - content.iospress.com
… only on the integrin subunit CD18 present in all beta 2-integrins. … From this analysis were
excluded subjects with infections. … use of a monoclonal antibody to the leukocyte CD11/CD18

Integrins in Health and Disease—Suitable Targets for Treatment?

T Klaus, C Hieber, M Bros, S Grabbe - Cells, 2024 - mdpi.com
… , the β2 integrin subfamily is characterized by leukocyte-restricted … integrin α subunits and 8
β subunits can be expressed [1,6,7], … Activated LFA1 engages ICAM 1–5, junctional adhesion …

Integrin CD11b contributes to hypertension and vascular dysfunction through mediating macrophage adhesion and migration

QY Lin, J Bai, YL Zhang, HH Li - Hypertension, 2023 - Am Heart Assoc
… were examined using histology and aortic ring analysis. Cell … Leukocyte integrins consist
of a common beta subunit (CD18… by interactions with integrins (CD11b/CD18, LFA-1, etc) and …

Quantitative Protein Sulfenic Acid Analysis Identifies Platelet Releasate-Induced Activation of Integrin β2 on Monocytes via NADPH Oxidase

R Li, C Klockenbusch, L Lin, H Jiang… - Journal of proteome …, 2016 - ACS Publications
Integrin β 2 , also designated as CD18, forms complexes with various integrin α subunits
and mediates leukocyteintegrin β 2 , we measured the activity level of LFA-1 and Mac-…