Circadian clock genes modulate human bone marrow mesenchymal stem cell differentiation, migration and cell cycle

H Boucher, V Vanneaux, T Domet, A Parouchev… - PLoS …, 2016 - journals.plos.org
… , the mechanisms by which CR may regulate stem cellafter downregulation of Per2 in
murine breast cancer cells [51], and cyclin D1-dependent cell cycle deregulation in Per2 -/- mice

Comparing circadian dynamics in primary derived stem cells from different sources of human adult tissue

EH Rogers, SA Fawcett… - Stem cells …, 2017 - Wiley Online Library
… which showed clear circadian rhythm in mice adipose tissue [… adult mesenchymal stem cells
from different human tissue … in adult stem cells initially following dexamethasone or rhythmic …

Bmal1-and Per2-mediated regulation of the osteogenic differentiation and proliferation of mouse bone marrow mesenchymal stem cells by modulating the Wnt/β …

J Zheng, L Zhang, Z Tan, Q Zhao, X Wei… - Molecular Biology …, 2022 - Springer
… Bmal1 and Per2 are the core components of the circadian … In summary, we proposed the
following hypothesis: Bmal1 and … mol/l dexamethasone, 0.05 mmol/l vitamin C and 10% fetal …

miR-181a modulates circadian rhythm in immortalized bone marrow and adipose derived stromal cells and promotes differentiation through the regulation of PER3

M Knarr, AB Nagaraj, LJ Kwiatkowski, A DiFeo - Scientific Reports, 2019 - nature.com
… umbrella term of “mesenchymal stromal/stem cells”. Mounting … After dexamethasone treatment
the cells were washed with … with diabetic inflammation in mice and humans so it could be …

The circadian regulator Bmal1 in joint mesenchymal cells regulates both joint development and inflammatory arthritis

LE Hand, SH Dickson, AJ Freemont, DW Ray… - Arthritis Research & …, 2019 - Springer
… were replaced after 3 days, and on day 6, the bone marrow-… and tissues were synchronised
(200 nM dexamethasone, 1 h)… in mesenchymal stem cell differentiation towards a bone-…

Effects of dexamethasone concentration and timing of exposure on chondrogenesis of equine bone marrow–derived mesenchymal stem cells

S Tangtrongsup, JD Kisiday - Cartilage, 2016 - journals.sagepub.com
… accumulation after dexamethasone was … mouse anti-collagen type II IgG primary antibody
using undiluted supernatant (Hybridoma Bank, Iowa City, IA) followed by donkey anti-mouse

The circadian clock has roles in mesenchymal stem cell fate decision

W Gao, R Li, M Ye, L Zhang, J Zheng, Y Yang… - Stem Cell Research & …, 2022 - Springer
… For example, compared with bone marrow stem cells (… After circadian synchronisation by
dexamethasone, PER2 … mice will affect the offspring’s circadian rhythm and lead to decreased …

Clock-modified mesenchymal stromal cells therapy rescues molecular circadian oscillation and age-related bone loss via miR142-3p/Bmal1/YAP signaling axis

S Cha, J Wang, SM Lee, Z Tan, Q Zhao, D Bai - Cell Death Discovery, 2022 - nature.com
… (BMSCs) from young adult and aged adult mice. miRNAs … vivo, which may promote
regeneration after damage. Another … medium supplied with 1 mM dexamethasone, 10 nM insulin …

The shift in the balance between osteoblastogenesis and adipogenesis of mesenchymal stem cells mediated by glucocorticoid receptor

L Han, B Wang, R Wang, S Gong, G Chen… - Stem cell research & …, 2019 - Springer
… of the stress response and circadian rhythm. The pharmacological … in dexamethasone (DEX)-induced
osteoporotic mouse model … After that, other tissue-derived human MSCs have been …

MicroRNA-433 dampens glucocorticoid receptor signaling, impacting circadian rhythm and osteoblastic gene expression

SS Smith, NS Dole, T Franceschetti, HC Hrdlicka… - Journal of Biological …, 2016 - ASBMB
… We show that in mouse calvaria, miR-433 displays robust circadianCircadian mechanisms
in murine and human bone marrow mesenchymal stem cells following dexamethasone