Cytokine storm signature in patients with moderate and severe COVID-19

O Kalinina, A Golovkin, E Zaikova, A Aquino… - International Journal of …, 2022 - mdpi.com
… In this study, multiplex analysis revealed that 22 out of 47 … showed decreased monocyte
counts compared to the HD. … plasma extracellular vesicles levels using high-sensitivity flow

Immunophenotyping of lymphocytes and monocytes and the status of cytokines in the clinical course of Covid‐19 patients

UO Idiz, TT Yurttas, S Degirmencioglu… - Journal of medical …, 2022 - Wiley Online Library
… and cytokine storm develop which causes rapid clinical … patterns that are recognized by
extracellular toll-like receptors (… A study showed that the number of monocytes increased in mild …

… readily detectable morphological and inflammation-related phenotypic changes in peripheral blood monocytes, the severity of which correlate with patient outcome

D Zhang, R Guo, L Lei, H Liu, Y Wang, Y Wang, H Qian… - MedRxiv, 2020 - medrxiv.org
… To further confirm this suspicion, we performed intracellular … They also showed that these
monocytes had the capability of … patients, in association with cytokine storm. They described a …

Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity

L Vanderbeke, P Van Mol, Y Van Herck… - Nature …, 2021 - nature.com
… a correlation network of input genes (in this case, genes coding for plasma cytokines detected
in … First, we examined neutrophil activation status and neutrophil extracellular trap (NET) …

Severe COVID-19 is characterized by the co-occurrence of moderate cytokine inflammation and severe monocyte dysregulation

B Bonnet, J Cosme, C Dupuis, E Coupez, M Adda… - …, 2021 - thelancet.com
… In addition, we show that patients with a major cytokine stormclinical trial, published in the
summer of 2020, showed the … ) Spearman correlation of HLA-DR expression on monocytes

Surviving the storm: cytokine biosignature in SARS-CoV-2 severity prediction

R Ahmad, M Haque - Vaccines, 2022 - mdpi.com
… sequencing [66] and another flow cytometry study [67] noted … in monocytes in the periphery,
suggesting that cytokine storm … Furthermore, a correlation was detected between IL-6 levels …

The signal pathways and treatment of cytokine storm in COVID-19

L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - Signal transduction and …, 2021 - nature.com
… closely correlated with the illness severity. Laboratory results … neutrophil extracellular
traps (NETs) to kill extracellularmonocyte–macrophages from the same patient revealed a …

Decrease of non‐classical and intermediate monocyte subsets in severe acute SARS‐CoV‐2 infection

A Gatti, D Radrizzani, P Viganò, A Mazzone… - Cytometry Part …, 2020 - Wiley Online Library
… of cytokine storm induces extensive lung damage, and … age of 66 years showed a severe
acute clinical picture. Five … study that also included intracellular cytokine measurements (7), …

VISTA: a target to manage the innate cytokine storm

MA ElTanbouly, Y Zhao, E Schaafsma… - Frontiers in …, 2021 - frontiersin.org
… agonist treated human monocytes revealed a profound shift … had a striking positive correlation
with evolving disease … VISTA extracellular domain was necessary for binding as revealed

Cytokine storm—definition, causes, and implications

D Jarczak, A Nierhaus - International journal of molecular sciences, 2022 - mdpi.com
… NETs are diffuse extracellular structures consisting of a … In summary, they showed that
systemic levels of IL-6 in patients with … If monocytes fail to restore HLA-DR expression, the clinical