[HTML][HTML] Navigating multi-scale cancer systems biology towards model-driven clinical oncology and its applications in personalized therapeutics

MN Gondal, SU Chaudhary - Frontiers in Oncology, 2021 - frontiersin.org
… of personalized cancer therapeutics, and (iv) translational … Although ContraCancrum’s
project has created numerous … for developing a clinically driven cancer model repository. The …

[HTML][HTML] The INTEGRATE project: delivering solutions for efficient multi-centric clinical research and trials

H Kondylakis, B Claerhout, M Keyur, L Koumakis… - Journal of biomedical …, 2016 - Elsevier
… , ranging from basic, translational and clinical researchers to the pharmaceutical industry,
to … analysis of large multi-level clinical datasets and the derivation of predictive models. Its …

Navigating Multi-scale Cancer Systems Biology towards Model-driven Personalized Therapeutics

MN Gondal, SU Chaudhary - bioRxiv, 2021 - biorxiv.org
… scales have limited translational potential as cancer dysregulation is driven by tightly coupled
ContraCancrum’s project has created numerous avenues for multilevel cancer model

Tailoring multi-omics to inflammatory bowel diseases: all for one and one for all

P Sudhakar, D Alsoud, J Wellens… - Journal of Crohn's …, 2022 - academic.oup.com
… design of any research project generating such datasets. … , 49 ContraCancrum, 50 p-medicine,
51 and CHIC 52] have also been undertaken to create a translational framework in cancer

Clinical implications of in silico mathematical modeling for glioblastoma: a critical review

M Protopapa, A Zygogianni, GS Stamatakos… - Journal of neuro …, 2018 - Springer
… This is crucial in the translation of mathematical oncology in … [34] developed a new grow-or-go
multilayer model for GBM to … the very ambitious ContraCancrum project, a computational …

… : quantification of the in vivo antitumor efficacy of cisplatin-based doublet therapy in non-small cell lung cancer (NSCLC) through a multiscale mechanistic model

E Kolokotroni, D Dionysiou, C Veith… - PLoS Computational …, 2016 - journals.plos.org
… state, clinically oriented simulation model of tumor response … ] (Contra Cancrum: Clinically
Oriented Translational Cancer … patients and tumor tissue of the Contra Cancrum project were …

PML differentially regulates growth and invasion in brain cancer

M Tampakaki, ME Oraiopoulou, E Tzamali… - International Journal of …, 2021 - mdpi.com
… Mathematical mechanistic models are commonly used to allow deeper understanding and …
mechanisms involved in tumor progression [20] and even proposals for clinical translation [21]…

[HTML][HTML] Emerging and established trends to support secure Health Information Exchange

EG Spanakis, S Sfakianakis, S Bonomi… - Frontiers in Digital …, 2021 - frontiersin.org
… To do so, we analyze health information sharing within the concept of the PANACEA project
… as a common, multilevel, and multi-perspective model on the interoperability requirements. …

[HTML][HTML] Multi-scale network targeting: A holistic systems-biology approach to cancer treatment

D Paul, NL Komarova - Progress in biophysics and molecular biology, 2021 - Elsevier
… We have used mathematical modeling to address several types of questions related to the
functioning of healthy tissues and cancer formation. This system of stochastically dividing and …

Cyber-attacks and threats for healthcare–a multi-layer thread analysis

EG Spanakis, S Bonomi, S Sfakianakis… - 2020 42nd Annual …, 2020 - ieeexplore.ieee.org
… This work presents the effort within the context of PANACEA project (www.panacearesearch.…
of creating a model that would allow us to represent in the form of a multilayer attack graph …