Functional human oocytes generated by transfer of polar body genomes

H Ma, RC O'Neil, NM Gutierrez, M Hariharan, ZZ Zhang… - Cell stem cell, 2017 - cell.com
… into donor cytoplasm may offer a source of oocytes for … and performed array comparative
genomic hybridization (array CGH) … This outcome was comparable to that of controls with one of …

Next generation sequencing-based comprehensive chromosome screening in mouse polar bodies, oocytes, and embryos

NR Treff, RL Krisher, X Tao, H Garnsey… - Biology of …, 2016 - academic.oup.com
… age conceive using donor oocytes from reproductively young individuals, … whole-genome
amplification (WGA) with subsequent analysis by array comparative genomic hybridization, …

Polar body transfer restores the developmental potential of oocytes to blastocyst stage in a case of repeated embryo fragmentation

SP Zhang, CF Lu, F Gong, PY Xie, L Hu… - Journal of Assisted …, 2017 - Springer
… pronuclei of human oocytes revealed the genome integrity of all … [6] used array comparative
genomic hybridization and … Considering the young age of oocyte donors in this study, the …

The methylome of a human polar body reflects that of its sibling oocyte and its aberrance may indicate poor embryo development

P Yuan, Q Guo, H Guo, Y Lian, F Zhai, Z Yan… - Human …, 2021 - academic.oup.com
… who receive oocytes from young and fertile donors have a higher pregnancy rate compared
with those who use oocytes from older donors. The chromosomes of the polar body (PB1) …

Mitochondrial replacement in macaque monkey offspring by first polar body transfer

Z Wang, Y Li, X Yang, Y Wang, Y Nie, Y Xu, X Zhang… - Cell Research, 2021 - nature.com
first investigated the genomic integrity of the first polar body … Single-cell array comparative
genomic hybridization (aCGH) … oocytes by PB1T using PB1s from one female monkey donor

Direct single-cell analysis of human polar bodies and cleavage-stage embryos reveals no evidence of the telomere theory of reproductive ageing in relation to …

K Turner, C Lynch, H Rouse, V Vasu, DK Griffin - Cells, 2019 - mdpi.com
… length directly in human oocytes or preimplantation embryos. … , and blastomeres originating
from the same donors. … first polar bodies in women aged 35 years or younger (n = 11) in …

Human pericentromeric tandemly repeated DNA is transcribed at the end of oocyte maturation and is associated with membraneless mitochondria-associated …

MA Dobrynin, NM Korchagina, AD Prjibelski… - Scientific reports, 2020 - nature.com
… I (with extrusion of the first polar body), and progression to … ) and persists briefly in young
primordial follicles. In growing … consent was signed by the donor. The degree of meiotic cell …

Somatic cell nuclear transfer in non-enucleated goldfish oocytes: understanding DNA fate during oocyte activation and first cellular division

C Rouillon, A Depincé, N Chênais, PY Le Bail… - Scientific reports, 2019 - nature.com
oocytes are less suitable for donorpolar body to identify how DNAs were handled by the
oocyte environment. Then, we characterized the organization of the blastomere during the first

Sperm and oocyte chromosomal abnormalities

O Samura, Y Nakaoka, N Miharu - Biomolecules, 2023 - mdpi.com
… using surplus oocytes and polar bodies for preimplantation … using array comparative
genomic hybridization (aCGH) and … Oocytes from young women under 20 years of age tend to …

Embryos derived from donor or patient oocytes are not different for in vitro fertilization outcomes when PGT allows euploid embryo selection: a retrospective study

E Schaeffer, LM Porchia, A Neumann… - Clinical and …, 2020 - Wiley Online Library
… either microarray-comparative genomic hybridization (aCGH) … ), quality of the cytoplasm,
zona pellucida, and polar body]. … The typical donor is fertile, young women, who are more likely …