… The BACE1 antisense transcript (BACE1-AS) is a conserved … Aβ 1-42 induces BACE1
expression and Aβ generation is … β-Site APP cleaving enzyme 1 (BACE1) is an endogenous …

… the role of Aβ and BACE1 in physiological processes and key … also decrease acetylated H3
to reduce BACE1 transcripts (21). On … High BACE1 enzymatic activity was found in human AD …

… β-site APP cleaving enzyme 1 (BACE1) cleaves APP at minor Asp … Activation of the
exogenous APP gene transcription in the … subsequent Aβ generation compared with APP Wt . …

… protein (APP) by β-site APP-cleaving enzyme (BACE1). Here, … We show that SEPT8
affects APP processing and Aβ peptide … BACE1 protein levels is regulated at the post-transcriptional …

… of BACE1 and BACE1-AS transcripts and Aβ production and … of NRF2 can prevent a key
early pathogenic process in AD. … While drugs that inhibit BACE1 enzyme activity are being …

… as a repressor of APP, BACE1, and the two primary forms of Aβ (… Each reaction contained
1.3 μl of reverse transcription … effects against abnormal APP processing and Aβ-toxicity in AD […

… enzyme (BACE), and this protease has increased activities in … % of BACE1 activity, and the
specific β-secretase activity was … The level of BACE transcripts was only slightly higher in d0 …

… In fact, BACE1 is the initiating and rate-limiting enzyme in Aβ … the protein level of sAPPβ and
attenuated Aβ generation in APP-… BACE1 activity by inhibiting transcription and translation of …

… an optimal environment for BACE1 enzymatic activity and APP cleavage 22. While … that
AP‐2 affects APP processing and Aβ production in neurons via the regulation of BACE1 …

… of BACE1 inhibitors on its opposing enzymatic functions, ie, … , and actin (control), or cell
media for secreted sAPPβ. B–E, … of BACE1, APP, sAPPβ, or mature APP as a function of BACE1 …