… Hence, organisms established a defense system known as the DNA repair process (broader
term: DNA damage response abbreviated as DDR). The importance of this field was …

… This review highlights the DDR pathways in cancer therapy, its role in the resistance to
conventional treatments, and its exploitation for anticancer treatment. Biomarkers of …

… In addition to the role of cGAS in catalyzing cGAMP synthesis, researchers found that in the
case of DNA damage caused by hydrogen peroxide treatment, phosphorylation at Tyr215 of …

… number of anticancer treatments [8–11… therapeutic effect against cancer by therapy tailored
to augment cellular ROS level. Oxidative damage is believed a potential double-edged sword …

… and Rad3-related (ATM/ATR) repair response, which through applying p53 and its … cancer
and inflammatory mediators such as ROS and NOS may induce DNA damage and cancer …

… tumor progression via inducing DNA damage [21]. ROS induces gene mutations and structural
changes in the DNA and results in DNA damage … standard anticancer treatment options …

… DNA damage and subsequently cancer cell death. It also sensitizes drug-resistant cancer
cells and increases the anticancer … Recently, anticancer therapies that induce oxidative stress …

… DNA damage is a double-edged sword in cancer cells. On the one hand, DNA damage …
CHK1 plays an important role in DNA damage response and DNA damage repair. The …

… Recent evidence suggests that DAMPs may also have a key role in the development of
cancer, as well as in the host response to cytotoxic anti-tumor therapy. As such, DAMPs may …

… damage with ensuing cell death, but DNA damage … tumor formation and growth, and also
nurture the tumor microenvironment and metastasis. However, Fe can also contribute to cancer …