[HTML][HTML] Design of multiepitope vaccine candidate from a major capsid protein of the African swine fever virus
AB Rowaiye, AN Oli, MT Asala, EJ Nwonu, MO Njoku… - Veterinary Vaccine, 2023 - Elsevier
This study unveils immunodominant epitopes from the African Swine Fever Virus Major
Capsid protein and created a multiepitope vaccine candidate. Protein sequences of 42
strains of ASFV from 28 countries were selected. Binding to MHC proteins were predicted. T
and Linear B Lymphocytes epitopes were adopted and evaluated for antigenicity,
immunogenicity, allergenicity, and toxicity. Selected epitopes were modelled and
molecularly docked against the appropriate MHC proteins. An adjuvant and multiple linkers …
Capsid protein and created a multiepitope vaccine candidate. Protein sequences of 42
strains of ASFV from 28 countries were selected. Binding to MHC proteins were predicted. T
and Linear B Lymphocytes epitopes were adopted and evaluated for antigenicity,
immunogenicity, allergenicity, and toxicity. Selected epitopes were modelled and
molecularly docked against the appropriate MHC proteins. An adjuvant and multiple linkers …
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