Dysfunction of either the right or left ventricle can lead to heart failure (HF) and subsequent
morbidity and mortality. We performed a genome-wide association study (GWAS) of 16
cardiac magnetic resonance (CMR) imaging measurements of biventricular function and
structure. Cis-Mendelian randomization (MR) was used to identify plasma proteins
associating with CMR traits as well as with any of the following cardiac outcomes: HF, non-
ischemic cardiomyopathy, dilated cardiomyopathy (DCM), atrial fibrillation, or coronary heart …

Dysfunction of either the right or left ventricle can lead to heart failure (HF) and subsequent
morbidity and increased mortality. We performed a genome-wide association study (GWAS)
of 16 measurements of biventricular function and structure obtained from cardiac magnetic
resonance (CMR). We then used aggregated data from three independent plasma proteome
GWAS, and performed cis-Mendelian randomization (MR) to identify proteins with a likely
causal effect on biventricular traits. The subset of proteins with a robust CMR effect were …