… For example, the literature on the aging astrocyte is substantial, … aging vBBB. Here, we
focus on only the literature on healthy aging and do not review the much larger literature on age-…

… Although not the focus of this review, it is noteworthy to mention the existence of other
blood-brain/cerebrospinal fluid barriers that are essential for brain homeostasis. The meninges (…

… aging, AD and PD, there is growing evidence of altered structure and function of the blood-brain
barrier (… The subsequent impact on CNS drug exposure and risk of neurotoxicity from …

… the pathological processes in age-associated … blood–brain barrier and its supporting
mechanisms and also on their alterations during development, physiological aging process and age…

… Schematic representation of the blood–brain barrier (BBB) and the blood–cerebrospinal
fluid (CSF) barrier (BCSFB) in healthy conditions and aging. a The BCSFB is formed by choroid …

… affects neuronal functioning. Currently, dynamic contrast-enhanced (DCE) MRI is the preferred
in-vivo method to quantify BBB leakage. Dedicated DCE MRI studies in normal aging … age …

… However, it is less well understood how specific changes in the immune system with aging
… that brain barriers, especially the blood–brain barrier (BBB) and blood–CSF barrier (BCSFB)…

… The main characteristic of aging microvessels is degeneration affecting … blood-brain barrier
(BBB) integrity. It has been thought that increased BBB permeability (BBB leakage) in aging …

Aging occurs along with multiple pathological problems in various organs. The aged brain,
especially, shows a reduction in brain mass, neuronal cell death, energy dysregulation, and …

… However, in the process of healthy aging there might also be an increased “leakage…
consequences of advanced age on the blood-brain barrier during the process of physiological aging …