… of the cell types that modulate barrier function via intercellular communication, we examine
how age, age related pathologies and the aging of the immune system affects TJs. Then, we …

Cerebral endothelial cells and their linking tight junctions form a unique, dynamic and multi-functional
interface, the blood-brain barrier (BBB). The endothelium is regulated by …

… Blood-brain barrier (BBB) modeling in vitro is a huge area of research covering … Effects of
aging on blood brain barrier and matrix metalloproteases following controlled cortical impact …

… Schematic diagram shows the mechanisms of blood–brain barrier (BBB) breakdown in
normal aging. (1) Oxidative stress increases with age. (2) Oxidative stress triggers endothelial …

… Our knowledge of the pathophysiology involved in the regulation of blood-brain barrier
function in aging is growing, but this vascular contribution to cognitive impairment and dementia …

… Therefore, we aimed to characterize age-associated changes in the blood–brain barrier (…
It is likely, however, that blood–brain barrier (BBB) dysfunction has a contributory role in the …

… effects on BBB integrity in vivo using the accelerated aging BubR1 hypomorphic (BubR1 H/H
) mouse model, in which cellular senescence is causally implicated in age-related features. …

… The blood-brain barrier (BBB) is comprised of endothelial cells connected by tight junctions,
pericytes, and astrocytic end-feet, and regulates homeostasis of fluid and solutes at the …

… Indeed, dysfunctional astrocytes are implicated in age-related neuropathology and …
neuropathology in the aging brain. First, age-associated blood–brain barrier dysfunction (BBBD) …

… To investigate whether blood–brain barrier (BBB) disruption is a potential mechanism of
usual age-related cognitive decline, we conducted dynamic contrast–enhanced (DCE) MRI to …