… blood–brain barrier (BBB) leaks in the human brain during normal aging, in individuals with
age-… in neurovascular and neurodegenerative conditions and in the aging human brain. …

… the free movement of substances across the blood brain barrier. (Figure created using
BioRender.com). … Loss of this proteins lead to increase blood brain barrier (BBB) permeability. …

… between advanced age and changes in the integrity of the blood-brain barrier (BBB). These
… Age-associated downregulation of the efflux pumps ATP-binding cassette transporters (ABC …

… Moreover, due to the loss of the protective function of the blood-brain barrier (BBB), impaired
… In this review we illustrate the vascular risk factors, their effects on BBB function and their …

… This review will examine the ECM at the neurovascular unit (NVU) and the blood–brain barrier
(… a focus on changes in basement membrane ECM during aging and neurodegeneration. …

… The blood–brain barrier (BBB) was suggested to be the major … Moreover, age was described
as one of the most prominent risk … This review will discuss the impact of SARS-CoV-2 on the …

… Dysfunction of immune and vascular systems has been implicated in aging … age-dependent
increases in vascular inflammation, peripheral lymphocyte infiltration, and blood-brain barrier …

… Aging is the single most important risk factor for AD … at the blood-brain barrier are significantly
altered with age: the … role in aging alterations in blood-brain barrier receptor expression …

… Linear regression of blood–brain barrier opening volume over time reveals increased fitted
initial opening volume with age and AD. (A) BBBO targeting and representative MR axial and …

… Following ischemia, the blood–brain barrier is compromised … for blood–brain barrier
permeability, particularly with aging. … versus 72 h) to the blood–brain barrier in young adult and …