… BEC mitochondria decrease in number with aging [9,10], but this does not necessarily
decrease the amount of oxidative stress generated. In fact, oxidative stress is implicated in aging […

… Blood-brain barrier efflux of Aβ is impaired in the aging brain. In addition to BBB efflux, several
studies suggest that perivascular glymphatic exchange contributes to the clearance of Aβ …

… Aging and regular exercise may have opposite effects on … factors and reducing blood–brain
barrier permeability in the … are believed to play a major role in these effects. The positive …

… , we used ANOVA with WML volume, age, and gender as covariates and found that there
was no significant association between WML volume (or age or gender) and K trans . The main …

… Two distinct blood–CNS barriers exist: the endothelial “blood–brain barrier” (BBB), localized
at all levels of the cerebral vascular tree, and the epithelial “blood–cerebrospinal fluid barrier…

… diseases as well as blood–brain barrier (BBB) breakdown. In … (S100BKO) mice at 6 months
of age but not at 3 months. By 9 … in BBB permeability upon aging in S100BKO mice for the first …

… human BBB with increasing age 26-29. We hypothesized that an age-associated reduction
in … In the present study, we compared the effect of ABCB1 inhibition with the third-generation …

… In this article, we address how obesity affects the structure and function of the blood-brain
barrier (BBB), the impact of obesity on Alzheimer’s disease, the effects of obesity on circulating …

… damaging substances via the blood–brain barrier (BBB). Age-related anatomical changes
… in cerebral MVs in health and disease during aging has been relatively neglected due to the …

… the BBB in neurological diseases of aging, we treated hAPP(… a critical mediator of blood-brain
barrier breakdown in models … restoration of blood-brain barrier integrity in disease states. …