Stabilizing agents for drug nanocrystals: effect on bioavailability

A Tuomela, J Hirvonen, L Peltonen - Pharmaceutics, 2016 - mdpi.com
… Additionally, an absorption enhancer, polysorbate 80, was … also utilized as nanocrystal
stabilizers; hydroxypropylcellulose, (HPC, … , Vitamin E TPGS has physical properties that make it a …

Bioavailability enhancement of poorly soluble drugs: the holy grail in pharma industry

M Rashid, MY Malik, SK Singh… - Current …, 2019 - ingentaconnect.com
… a considerable effect on the absorption and bioavailability of the … successful in improving
physicochemical properties of CBZ. … approaches where DMSO, Tween 80, ethanol and organic …

Pharmaceutical dispersion techniques for dissolution and bioavailability enhancement of poorly water-soluble drugs

X Zhang, H Xing, Y Zhao, Z Ma - Pharmaceutics, 2018 - mdpi.com
… of dispersion plus absorption-promoting effect are intrinsically … physicochemical properties
of poorly water-soluble drugs whereby to enhance their dissolution rate and bioavailability

Improvement in the oral bioavailability and efficacy of new ezetimibe formulations—comparative study of a solid dispersion and different micellar systems

C Torrado-Salmerón, V Guarnizo-Herrero… - Pharmaceutics, 2020 - mdpi.com
… methylcellulose (HPMC), hydroxypropyl cellulose (HPC) and … Surfactants such as sodium
dodecyl sulphate, Tween 80 or … studies allow the physicochemical properties of SD and MS …

Significance of excipients to enhance the bioavailability of poorly water-soluble drugs in oral solid dosage forms: A Review

MK Vadlamudi, S Dhanaraj - IOP Conference Series: Materials …, 2017 - iopscience.iop.org
… , and subcutaneous due to its incomplete absorption at the site of action. Moreover, the …
with PEG and Polysorbate 80 will place a vital role in the bioavailability enhancement of poorly …

Effects of different physicochemical characteristics and supersaturation principle of solidified SNEDDS and surface-modified microspheres on the bioavailability of …

JE Choi, JS Kim, MJ Choi, K Baek, MR Woo… - International Journal of …, 2021 - Elsevier
… oral bioavailability of poorly water-soluble drugs. In this study, the release and bioavailability,
including the physical properties … on the solubility results, copovidone and Tween 80 were …

A novel electrospun hydroxypropyl methylcellulose/polyethylene oxide blend nanofibers: Morphology and physicochemical properties

A Aydogdu, G Sumnu, S Sahin - Carbohydrate polymers, 2018 - Elsevier
… the effects of HPMC and PEO content on physical propertiesTween 80 dissolved in water
and readily absorbed at … 5, the FTIR spectrum of HPMC powder, exhibited absorption bands at …

Development of universal formulation with superior re-dispersion using nanocrystal approach with simultaneous identification of API physicochemical properties

H Fujii, S Watano - Chemical and Pharmaceutical Bulletin, 2019 - jstage.jst.go.jp
… different polymer species (hydroxypropyl cellulose (HPC), … sodium, Pluronic surfactants,
tween 80, polyethylene glycol (… variation of absorption enhancement effect depending on the …

Updates on applications of low-viscosity grade Hydroxypropyl methylcellulose in coprocessing for improvement of physical properties of pharmaceutical powders

C Jin, F Wu, Y Hong, L Shen, X Lin, L Zhao… - Carbohydrate Polymers, 2023 - Elsevier
… , stability, and solubility have an impact on the quality of the … caused by moisture absorption
of excipients during the SD … As for hydroxypropyl cellulose (HPC), its lowest viscosity on …

New potential application of hydroxypropyl-β-cyclodextrin in solid self-nanoemulsifying drug delivery system and solid dispersion

JS Kim, YJ Choi, MR Woo, S Cheon, SH Ji, D Im… - Carbohydrate …, 2021 - Elsevier
… to enhance the solubility and oral bioavailability of poorly water-… physicochemical
properties, molecular interaction features, … Subsequently, the effect of the polysorbate 80/Cremophor® …