… , and the potential for therapeutic targeting of IL-1β-induced disruption of the intestinal TJ
barrier to prevent or treat intestinal inflammation. In summary, IL-1β is markedly elevated in …

… junctions that include an apical tight junction (TJ) and subjacent adherens junctions and …
The TJ tetraspan claudin proteins form pores between epithelial cells to control paracellular …

… Electron microscopy of pouch epithelium tight junction complex in non-inflamed pouch (A)
and electron micrograph demonstrating dendritic cell penetrating between two …

… of different inflammatory disorders contributing to the severity of disease. Barrier permeability
is controlled by epithelial adherens junctions and tight junctions. Junctional assembly and …

… In mucosal biopsies taken from IBD sufferers, localization studies have documented loss
of key epithelial tight junction (TJ) proteins, namely claudin-1, occludin, junctional adhesion …

… intestinal inflammation, consisting of HT-29 colon epithelial cells stimulated with cytokines
relevant in the context of intestinal inflammation … a significant intestinal anti-inflammatory effect …

… Intestinal epithelial tight junction (TJ) barrier dysfunction has been implicated as an …
factor of various inflammatory conditions of the gut, including inflammatory bowel disease (IBD), …

… epithelia tight junction integrity. Given that excessive colonic inflammation could cause
dysfunctional tight junction, … whether STAT6 directly regulated epithelial tight junction proteins and …

… epithelial TJ barrier or a leaky gut is an important pathogenic factor that … of intestinal
inflammation in inflammatory bowel disease (IBD) and other inflammatory conditions of the gut, …

… function as it actually contributes to intestinal tissue inflammation in certain mouse models (…
in the inflamed intestinal tissues that are often associated with altered tight junction structures …