CYP3A4*22 and CYP3A5*3 impact efficacy and safety of diazepam in patients with alcohol withdrawal syndrome

VY Skryabin, J Franck, VM Lauschke… - Nordic Journal of …, 2023 - Taylor & Francis
… revealed typical side effects such … CYP3A4*22 genetic polymorphisms and the efficacy
and safety of diazepam, as well as a correlation between the CYP3A5*3 genetic polymorphisms

How do CYP2C19* 2 and CYP2C19* 17 genetic polymorphisms affect the efficacy and safety of diazepam in patients with alcohol withdrawal syndrome?

VY Skryabin, MS Zastrozhin, MV Torrado… - Drug metabolism and …, 2020 - degruyter.com
… by CYP3A4 in liver microsomes [11], [12]. Recent studies revealed the effect of CYP2C19
and CYP3A4 genetic polymorphisms on … The UKU side effect rating scale was designed to be …

Associations of CYP3A4* 22 polymorphism with phenazepam's safety in patients with alcohol withdrawal syndrome

DV Ivashchenko… - …, 2018 - pharmacogenetics …
side effects did not differ significantly between carriers of polymorphic and wild-type CYP3A4*22
variants. In CYP3A4*22 carriers was observed trend towards significance in increase of …

Using the CYP3A activity evaluation to predict the efficacy and safety of Diazepam in patients with alcohol withdrawal syndrome

VY Skryabin, MS Zastrozhin… - Journal of …, 2022 - journals.sagepub.com
effect of CYP2C19 and CYP3A4 genetic polymorphisms on the pharmacokinetics of BZDs.
The differences in the activity of these enzymes are genetically … undesirable side effects and …

… of the safety of phenazepam in alcohol withdrawal syndrome: haplotype and combinatorial analyses of polymorphic variants in the pharmacokinetic factor genes

DV Ivashchenko, OV Tereshchenko… - Neurology …, 2020 - nnp.ima-press.net
… оценки нежелательных эффектов (UKU Side Effect Rating Scale). … , CYP2D6 and ABCB1
gene polymorphisms and the safety of … и безопасность субстратов CYP3A4 [16]. Наи- …

Influence of CYP2D6, CYP3A4, CYP3A5 and ABCB1 Polymorphisms on Pharmacokinetics and Safety of Aripiprazole in Healthy Volunteers

C Belmonte, D Ochoa, M Román… - Basic & Clinical …, 2018 - Wiley Online Library
… The subjects were free to withdraw from the study at any time… that although it seems CYP3A4
enzyme plays an important … to evaluate the effect of genetic polymorphisms on the response …

Role of CYP2C19 gene polymorphism in acute alcohol withdrawal treatment with loading dose of diazepam in a South Indian population

M Jose, J Mathaiyan, S Kattimani, S Adithan… - European journal of …, 2016 - Springer
… We studied the effect of CYP2C19 gene polymorphisms on … , at higher doses may lead to
several side effects as it is a central … CYP3A4 polymorphisms are less common in India and thus …

[HTML][HTML] Effect of the most relevant CYP3A4 and CYP3A5 polymorphisms on the pharmacokinetic parameters of 10 CYP3A substrates

M Saiz-Rodríguez, S Almenara, M Navares-Gómez… - Biomedicines, 2020 - mdpi.com
… Subjects were free to withdraw from the study at any time. … Nevertheless, this study design
allows the investigation of genetic polymorphisms affecting PK while avoiding the influence of …

Polymorphisms associated with fentanyl pharmacokinetics, pharmacodynamics and adverse effects

M Saiz‐Rodríguez, D Ochoa, C Herrador… - Basic & clinical …, 2019 - Wiley Online Library
… They were free to withdraw from the study at any time. The … is the first study to associate
the CYP3A4*22 variant with the … can assess the effect of genetic polymorphisms over fentanyl …

[PDF][PDF] Investigation of cytochrome p450 CYP1A2, CYP2D6, CYP2E1 and CYP3A4 gene expres-sions and polymorphisms in alcohol with-drawal

N Taşçıoğlu, Ç Saatçi, R Emekli, G Tuncel… - Turk. J. Clin …, 2021 - jag.journalagent.com
… to alcohol addicts to reduce withdrawal symptoms may not have reached … studies about
CYP3A4 gene polymorphisms in the Turkish … should be made for drug side effects in our society. …